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" Prostaglandin E1 in Atherosclerosis "
edited by Helmut Sinzinger, Waltraud Rogatti.
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BL
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| Record Number
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739863
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b559794
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| Main Entry
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edited by Helmut Sinzinger, Waltraud Rogatti.
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| Title & Author
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Prostaglandin E1 in Atherosclerosis\ edited by Helmut Sinzinger, Waltraud Rogatti.
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| Publication Statement
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Berlin, Heidelberg: Springer Berlin Heidelberg, 1986
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| Page. NO
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(xii, 112 pages 35 illustrations)
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| ISBN
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3642716792
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: 9783642716799
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| Contents
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Pharmacological Actions of Prostaglandin E1 --;Biochemistry and Pharmacology of Prostaglandin E1: Introductory Remarks --;On the Metabolism of Prostaglandin E1 in Patients Suffering from Arterial Occlusive Disease --;Effects of Prostaglandins on Platelet Function Ex Vivo and in Animal Thrombosis Models --;Different Effects of E- and I-Type Prostaglandins on Human Platelet and Polymorphonuclear Cell Function --;Effects of Prostaglandin E1 on Low Density Lipoprotein Receptor Activity and Cholesterol Synthesis in Freshly Isolated Human Mononuclear Leukocytes --;Inhibition of Mitotic and Proliferative Activity of Smooth Muscle Cells by Prostaglandin E1 --;The Effect of Intra-Arterial and Intravenous Prostaglandin E1 in a Model of Ischaemia in Healthy Volunteers --;Clinical Results with Prostaglandin E1 --;Prospective Open Pilot Study to Investigate the Effects of Intermittent Intra-Arterial Infusion Treatment with Prostaglandin E1 in Patients with Intermittent Claudication --;Treatment of Stage IIb Peripheral Arterial Occlusive Disease with Short-Term Intra-Arterial Infusion of Prostaglandin E1 --;Clinical Efficacy of Intra-Arterial PGE1-Infusion in Intermittent Claudication: A Double-Blind Study --;Prostaglandin E1 in Arterial Occlusive Disease in Stages III and IV According to Fontaine --;Long-Term Intravenous Infusion of PGE1 in Peripheral Arterial Blood Flow Disorders: Results of an Open Screening Study with Patients in Fontaine's Stages III and IV --;Experiences with PGE1 in Patients with Phlegmasia Coerulea Dolens and in Ergotism --;PGE1 in Patients with Macular Degeneration.
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| Abstract
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Prostaglandins were discovered in the early 1930s following research into their extremely potent biological effects. During the last decade especially two com pounds sharing the same receptor on the platelet surface, the antiaggregatory prostaglandins PGE and PGI, attracted considerable interest in cardiovascular 1 2 medicine. Since 1973 PGE has been widely used in the therapy of peripheral vascular 1 disease. Although its effects on platelet function, smooth muscle cells, vascular wall cell lipid metabolism, red cell deformability and plasmatic coagulation are well known, these factors altogether do not fully explain the efficacy of PG El in the therapy of advanced atherosclerosis. This book is the outcome of a workshop organised by Schwarz GmbH (Mon heim, FRG) which was held at Stresa, Italy, in April 1986. The coming together of researchers and clinicians produced a survey of the chemistry, physiology, pharmacology and clinical efficacy of PGE which will serve as a new insight 1 into the complexity of basic and clinical applications of PGE - 1 Helmut Sinzinger Waltraud Rogatti Table of Contents Pharmacological Actions of Prostaglandin E.
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| Subject
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Cardiology.
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Endocrinology.
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Medicine.
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| LC Classification
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RC692.E358 1986
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| Added Entry
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H Sinzinger
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Waltraud Rogatti
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