| Document Type
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BL
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| Record Number
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739957
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| Doc. No
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b559890
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| Main Entry
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edited by Randall E. Harris.
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| Title & Author
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COX-2 blockade in cancer prevention and therapy\ edited by Randall E. Harris.
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| Publication Statement
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Totowa, N.J.: Humana Press, ©2003.
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| Series Statement
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Cancer drug discovery and development.
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| Page. NO
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(x, 371 pages) : illustrations (some color)
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| ISBN
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058543882X
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: 159259302X
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: 1617373044
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: 9780585438825
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: 9781592593026
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: 9781617373046
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| Contents
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I. Historical Perspectives --;l Dietary Fatty Acids, COX-2 Blockade, and Carcinogenesis --;2 Historical Aspects of COX-2: Cloning and Characterization of the cDNA, Protein and Gene --;II. Epidemiology of NSAIDS and Cancer --;3 Epidemiology of Nonsteroidal Anti-Inflammatory Drugs and Colorectal Cancer --;4 Epidemiology of Breast Cancer and Nonsteroidal Anti-Inflammatory Drugs: Extension of the Dietary Fat Hypothesis of Breast Cancer --;III. Animal Models of Carcinogenesis --;5 Role of Synthetic and Naturally Occurring Cyclooxygenase Inhibitors in Colon Cancer Prevention --;6 Chemoprevention of Breast Cancer by Nonsteroidal Anti-Inflammatory Drugs and Selective COX-2 Blockade in Animals --;7 The Role of Cyclooxygenase-2 in the Prevention and Therapy of Lung Cancer --;8 Nonsteroidal Anti-Inflammatory Drugs, Prostaglandins, and Apc-Driven Intestinal Tumorigenesis --;9 Cyclooxygenase-1 and Cyclooxygenase-2 Knockout Mice Provide Insights into Beneficial and Adverse Effects of Nonsteroidal Anti-Inflammatory Drugs --;IV. Molecular Biology of CXO --;10 Cyclooxygenase-2, Prostaglandins, and Colorectal Carcinogenesis --;11 Regulation of Expression and Potential Carcinogenic Role of Cyclooxygenase-2 --;12 Cyclooxygenase-2 and Cancer --;13 Interactions of Cyclooxygenase and Aromatase Pathways in Normal and Malignant Breast Cells --;14 Association of COX-2 and PPARs in Carcinogenesis and Chemoprevention --;15 Carcinogenesis Involving Cyclooxygenase and Lipoxygenase --;V. Clinical Applications --;16 The Development of Drugs that Target Cyclooxygenase-2 --;17 Chemoprevention of Cancer by NSAIDs and Selective COX-2 Blockade --;18 Potential for Inhibitors of Cyclooxygenase-2 to Enhance Tumor Radioresponse --;19 Potential Role of NSAIDs and COX-2 Blockade in Cancer Therapy --;20 Cyclooxygenase-2 Blockade in Cancer Prevention and Therapy: Widening the Scope of Impact.
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| Abstract
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A section on animal models of carcinogenesis presents comprehensive evidence that general NSAIDs inhibit a variety of malignant neoplasms in vivo, and highlights recent findings which show that COX-2 blocking agents produce striking chemopreventive effects against colon cancer and breast cancer as well as other malignancies.
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| Subject
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Cancer -- Chemoprevention.
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| Subject
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Cyclooxygenase 2 -- Inhibitors -- Therapeutic use.
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| Subject
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Nonsteroidal anti-inflammatory agents.
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| LC Classification
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RC268.15E358 2003
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| Added Entry
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Randall E Harris
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| Parallel Title
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COX-two blockade in cancer prevention and therapy
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