|
" Voltage-gated ion channels as drug targets "
edited by David J. Triggle [and others].
| Document Type
|
:
|
BL
|
| Record Number
|
:
|
743609
|
| Doc. No
|
:
|
b563557
|
| Main Entry
|
:
|
edited by David J. Triggle [and others].
|
| Title & Author
|
:
|
Voltage-gated ion channels as drug targets\ edited by David J. Triggle [and others].
|
| Publication Statement
|
:
|
Weinheim : Wiley-VCH, ©2006.
|
| Series Statement
|
:
|
Methods and principles in medical chemistry, v. 29.
|
| Page. NO
|
:
|
(xii, 479 pages) : figure (some color), table
|
| ISBN
|
:
|
3527607749
|
|
|
:
|
: 3527608141
|
|
|
:
|
: 9783527607747
|
|
|
:
|
: 9783527608140
|
| Contents
|
:
|
Introduction : on ion channels / Murali Gopalakrishnan, David Rampe, David Triggle, Wei Zheng --; The voltage-gated ion channel superfamily / William A. Catterall --; State-dependent drug interactions with ion channels / Stefan I. McDonough, Bruce P. Bean --; Assay technologies : techniques available for quantifying drug-channel interactions / Derek Leishman, Gareth Waldron --; Overview of voltage-gated calcium channels / Clinton Doering, Gerald Zamponi --; Drugs active at T-type Ca² channels / Thomas M. Connolly, James C. Barrow --; L-type calcium channels / David J. Triggle --; N-type calcium channels --; Molecular, biophysical and functional properties of voltage-gated sodium channels / Douglas S. Krafte, Mark Chapman, Ken McCormack --; Small molecule blockers of voltage-gated sodium channels / Jesús E. González, Andreas P. Termin, Dean M. Wilson --; Potassium channels : overview of molecular, biophysical and pharmacological properties / Murali Gopalakrishnan, Char-Chang Shieh, Jun Chen --; Kv1.3 potassium channel : physiology, pharmacology and therapeutic indications / K. George Chandy, Heike Wulff, Christine Beeton, Peter A. Calabresi, George A. Gutman, Michael Pennington --; Drugs active at kv1.5 potassium channels / Stefan Peukert, Heinz Gögelein --; Medicinal chemistry of Ca²-activated K channel modulators / Sean C. Turner, Char-Chang Shieh --; Drugs active at ATP-sensitive K channels / William A. Carroll --; Compounds that activate KCNQ(2-5) family of potassium ion channels / Grant McNaughton-Smith, Alan D. Wickenden --; Inherited disorders of ion channels / Kate Bracey, Dennis Wray --; Structural and ligand-based models for HERG and their application in medicinal chemistry / Yi Li, Giovanni Cianchetta, Roy J. Vaz --; Ion channel safety issues in drug development / Armando A. Lagrutta, Joseph J. Salata.
|
| Abstract
|
:
|
Edited by the most prominent person in the field and top researchers at US pharmaceutical companies, this is a unique resource for drug developers and physiologists seeking a molecular-level understanding of ion channel pharmacology. After an introduction to the topic, the authors evaluate the structure and function of ion channels, as well as related drug interaction. A section on assay technologies is followed by a section each on calcium, sodium and potassium channels. Further chapters cover genetic and acquired channelopathies, before the book closes with a look at safety issues in ion cha.
|
| Subject
|
:
|
Ion channels.
|
| Subject
|
:
|
Ion Channels.
|
| Subject
|
:
|
Membranes (Biology)
|
| |