| Document Type
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BL
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| Record Number
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743700
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b563648
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| Main Entry
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edited by Klaus Gubernator, Hans-Joachim Böhm.
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| Title & Author
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Structure-based ligand design\ edited by Klaus Gubernator, Hans-Joachim Böhm.
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| Publication Statement
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Weinheim ; New York : Wiley-VCH, ©1998.
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| Series Statement
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Methods and principles in medicinal chemistry, v. 6.
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| Page. NO
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(xiv, 153 pages) : illustrations
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| ISBN
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3527612165
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: 3527612173
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: 9783527612161
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: 9783527612178
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| Contents
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Rational Design of Bioactive Molecules Examples of Active Areas of Structure-Based Design From Renin to HIV-1 Protease Zinc Endoproteases: A Structural Superfamily Structure-Based Design of Potent Beta-Lactamase Inhibitors Inhibition of Sialidase Rational Design of Inhibitors of HIV-1 Reverse Transcriptase New Computational Approaches to Predict Protein-Ligand Interactions The Future of Structure-Based Design: A Worthy Precept?
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| Abstract
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Most drugs bind to a clearly defined macromolecular target that is complementary in terms of structure and chemistry. This observation is the basic paradigm of structure-based ligand design. Although this method first emerged in the 1980s, it has already become a powerful tool for pharmaceutical research. Much has been learned, however, since the first attempts to discover drugs on the basis of available biochemical and structural data. Nowadays, structure-based ligand design is an established method for creating drugs with new structural features, for modifying binding activities and pharmaco.
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| Subject
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Ligand binding (Biochemistry)
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| Subject
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Pharmaceutical chemistry.
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| Subject
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QSAR (Biochemistry)
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| LC Classification
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QP624.75.D77E358 1998
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| Added Entry
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Hans-Joachim Böhm
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Klaus Gubernator
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