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" Molecular Mimicry : "
Michael B A Oldstone
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BL
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| Record Number
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745719
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b565668
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| Main Entry
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Michael B A Oldstone
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| Title & Author
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Molecular Mimicry : : Infection Inducing Autoimmune Disease.\ Michael B A Oldstone
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| Publication Statement
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Dordrecht : Springer-Verlag Berlin and Heidelberg & Co. KG, 2006
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| Page. NO
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(172 pages)
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| ISBN
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3540307915
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: 9783540307914
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| Contents
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Molecular Mimicry, Microbial Infection, and Autoimmune Disease: Evolution of the Concept; The Structural Interactions Between T Cell Receptors and MHC-Peptide Complexes Place Physical Limits on Self-Nonself Discrimination; A Virus-Induced Molecular Mimicry Model of Multiple Sclerosis; Suppression of Autoimmunity via Microbial Mimics of Altered Peptide Ligands; Molecular and Cellular Mechanisms, Pathogenesis, and Treatment of Insulin-Dependent Diabetes Obtained Through Study of a Transgenic Model of Molecular Mimicry; Trypanosoma cruzi -Induced Molecular Mimicry and Chagas' Disease. HTLV-1 Induced Molecular Mimicry in Neurological DiseaseMolecular Mimicry: Anti-DNA Antibodies Bind Microbial and Nonnucleic Acid Self-Antigens; Chlamydia and Antigenic Mimicry.
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| Abstract
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The conceptual basis for molecular mimicry was first defined in the early 1980s when monoclonal antibodies against viruses were also shown to react with non-viral host protein; in this case, measles virus phosphoprotein cross-reacted with host cell cytokeratin, herpes simplex virus type 1 with host-cell vimentin and vaccinia virus with host-cell intermediate filaments. Following this discovery, others emerged, again at the clonal level, that T cell clones against proteins from a variety of infectious agents also reacted with host antigenic determinants. The clonal distinction was imperative fo.
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| Subject
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Autoimmune diseases.
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| LC Classification
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RC600.M534 2006
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| Added Entry
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Michael B A Oldstone
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