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" DNA Repair "
edited by Fritz Eckstein, David M.J. Lilley.
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BL
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| Record Number
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749029
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b568986
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| Main Entry
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edited by Fritz Eckstein, David M.J. Lilley.
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| Title & Author
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DNA Repair\ edited by Fritz Eckstein, David M.J. Lilley.
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| Publication Statement
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Berlin, Heidelberg : Springer Berlin Heidelberg, 1998
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| Series Statement
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Nucleic acids and molecular biology, 12.
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(xi, 317 pages 64 illustrations, 19 illustrations in color.)
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| ISBN
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364248770X
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: 9783642487705
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| Contents
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Repair of alkylated DNA by the E. coli Ada protein / P.E. Verdemato and P.C.E. Moody --; Structural phylogenetics of DNA base excision repair / C.D. Mol [and others] --; Protein interactions in mammalian pathways of DNA base excision repair / R.A.O. Bennett and B. Demple --; Poly (ADP-Ribose) polymerase is required for maintenance of genomic integrity during base excision repair / G. De Murcia [and others] --; Functional domains of the E. coli UvrABC proteins in nucleotide excision repair / N. Goosen [and others] --; Nucleotide excision repair in yeast : recent progress and implications / E.C. Friedberg [and others] --; Nucleotide excision repair in man / R. Bessho and A. Sancar --; Transcription-coupled and global genome nucleotide excision repair / R.A. Verhage [and others] --; DNA mismatch repair / M. O'Driscoll, O. Humbert, and P. Karran --; Eukaryotic mismatch repair / P. Schär and J. Jiricny --; Conflicting roles of mismatch and nucelotide excision repair in cellular susceptibility to anticancer drugs / J.A. Mello [and others] --; Crystallographic studies of proteins involved in recombinational repair and excision repair --; K. Morikawa --; Eukaryotic DNA ligases and DNA repair / R. Bowater.
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| Abstract
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DNA is the central repository of genetic information in the cell, yet it is under constant attack by chemical mutagens, radiation and other processes. Cells therefore put a great deal of resources into repairing any damage to this precious store. Mechanisms of DNA repair vary greatly in their level of complexity, from specific reversal mechanisms that involve a single protein, to sequential pathways that require many enzymes. But at the heart of all these mechanisms lie proteins that recognize damage to DNA, raising important questions about how damaged DNA may be distinguished. These recognition processes are now finally yielding their secrets to structural analysis. This volume focuses on DNA repair, with an emphasis on structural data where available.
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| Subject
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Biochemistry.
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Cytology.
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Life sciences.
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| LC Classification
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QH467.E358 1998
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| Added Entry
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David M J Lilley
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Fritz Eckstein
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