| Document Type
|
:
|
BL
|
| Record Number
|
:
|
751652
|
| Doc. No
|
:
|
b571611
|
| Main Entry
|
:
|
Christine C. Stichel-Gunkel.
|
| Title & Author
|
:
|
The role of microenvironment in axonal regeneration : : influences of lesion-induced changes and glial implants on the regeneration of the postcommissural fornix\ Christine C. Stichel-Gunkel.
|
| Publication Statement
|
:
|
Berlin ; New York : Springer, ©1997.
|
| Series Statement
|
:
|
Advances in anatomy, embryology, and cell biology, v. 137.
|
| Page. NO
|
:
|
(viii, 81 pages) : illustrations
|
| ISBN
|
:
|
3642607810
|
|
|
:
|
: 9783642607813
|
| Contents
|
:
|
Introduction; - Axonal regeneration in the adult mammalian CNS --; Aims of the study --; Materials and methods --; Cell culture techniques --; Surgical procedures --; Tissue procedures --; Tissue processing --; Histological methods --; Immunohistochemical methods --; In situ-Hybridisation --; Quantitative analysis --; Results --; Unlesioned postcommissural fornix --; Sequence of cellular and molecular reactions following axonal transection --; Glial cell implantations --; Discussion --; Role of lesion-induced cellular and molecular changes in degeneration and regeneration --; The impact of glial implants on axonal regeneration --; Summary and perspectives --; References; - Subject Index.
|
| Abstract
|
:
|
Since the pioneering studies of Ramon y Cajal the inability of lesioned adult CNS axons to regenerate has been well established. During the past years advancements in molecular, cellular and biochemical knowledge have provided new insights into the extrinsic mechanims underlying regeneration failure. The rapid progress in this field has already led to the development of new concepts for therapeutic manipulations. This book provides a comprehensive overview of structural and molecular changes induced by an invasive CNS lesion and their involvements in regeneration processes. Moreover, it demonstrates the strong growth-promoting actitivies of implanted glial cells. The data is discussed in relation to current knowledge on the mechanisms of axonal degeneration and regeneration and in terms of their relevance for the development of novel therapeutic strategies.
|
| Subject
|
:
|
Axons.
|
| Subject
|
:
|
Nervous system -- Regeneration.
|
| Subject
|
:
|
Neuroglia.
|
| LC Classification
|
:
|
QP363.5C475 1997
|
| Added Entry
|
:
|
Christine C Stichel-Gunkel
|