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" Membrane Defenses Against Attack by Complement and Perforins "
edited by Charles J. Parker.
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BL
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| Record Number
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753638
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b573599
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| Main Entry
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edited by Charles J. Parker.
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| Title & Author
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Membrane Defenses Against Attack by Complement and Perforins\ edited by Charles J. Parker.
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| Publication Statement
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Berlin, Heidelberg : Springer Berlin Heidelberg, 1992
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| Series Statement
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Current topics in microbiology and immunology, 178.
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| Page. NO
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(viii, 188 pages 26 illustrations)
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| ISBN
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3642770142
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: 9783642770142
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| Contents
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List of Contents --; Regulation of Complement by Membrane Proteins: An Overview --; Decay Accelerating Factor (CD55) --; Complement Receptor Type 1 --; Membrane Cofactor Protein --; Membrane Inhibitor of Reactive Lysis --; Homologous Restriction Factor --; The Effects of Complement Activation on Platelets --; Effects of the Membrane Attack Complex of Complement on Nucleated Cells --; Glycosyl-Phosphatidylinositol Anchoring of Membrane Proteins --; Paroxysmal Nocturnal Hemoglobinuria --; Perforin-Structure, Function, and Regulation.
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| Abstract
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In this volume a comprehensive review of membrane proteins that regulate complement and perforin-mediated cytolysis is presented. A detailed analysisis provided of the biochemical, molecular, and functional features of these proteins; the glycosyl phosphatidylinositol linked proteins are covered, with emphasis placed on the functional importance of this type of membrane anchor. Further chapters include reviews of the effects of complement activation on cells that are metabolically active, and of the regulation of cell killing by cytotoxic lymphocytes, considering the similarities and disparities between the complement and perforin systems. The therapeutic use of recombinant CR1 for immune-mediated pathophysiological processes is discussed in a separate section.
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| Subject
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Biochemistry.
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Immunology.
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Medicine.
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| LC Classification
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QR1.E358 1992
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| Added Entry
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C J Parker
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