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" Quinolone antibacterials "
contributors, D. Beermann [and others] ; editors, J. Kuhlmann, A. Dalhoff, and H.-J. Zeiler.
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BL
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| Record Number
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754151
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b574113
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| Main Entry
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contributors, D. Beermann [and others] ; editors, J. Kuhlmann, A. Dalhoff, and H.-J. Zeiler.
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| Title & Author
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Quinolone antibacterials\ contributors, D. Beermann [and others] ; editors, J. Kuhlmann, A. Dalhoff, and H.-J. Zeiler.
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| Publication Statement
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Berlin ; New York : Springer, ©1998.
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| Series Statement
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Handbook of experimental pharmacology, v. 127.
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(xviii, 491 pages) : illustrations
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| ISBN
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3642803644
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: 9783642803642
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| Contents
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History and Introduction --; The Chemistry of the Quinolones: Methods of Synthesizing the Quinolone Ring System --; Chemistry in the Periphery of the Quinolones --; Mode of Action --; The In Vitro Antibacterial Activity of Quinolones: A Review --; Pharmacokinetics of Fluoroquinolones in Experimental Animals --; Pharmacodynamics of Fluoroquinolones in Experimental Animals --; Interaction of Quinolones with Host-Parasite-Relationships --; Mechanisms of Resistance to Fluoroquinolones --; Toxicology and Safety Pharmacology of Quinolones --; Clinical Pharmacology --; Concentration-Effect Relationship of the Fluoroquinolones --; Clinical Use of Quinolones --; Future Aspects.
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| Abstract
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The quinolones continue to make a significant contribution in the fight against community or hospital acquired infections and add a new dimension of antibacterial therapy. This volume describes in detail the chemistry, mode of action and pharmacodynamics of the quinolones. A lot of effort has been undertaken to optimize structure-activity relationships with the aim of producing more potent drugs with an optimal therapeutic index.
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Anti-Infective Agents -- therapeutic use.
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Quinolone antibacterial agents.
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Quinolones -- pharmacology.
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| LC Classification
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QP905.C668 1998
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| Added Entry
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Axel Dalhoff
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D Beermann
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H J Zeiler
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J Kuhlmann
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