|
" Microtubules "
by Pierre Dustin.
| Document Type
|
:
|
BL
|
| Record Number
|
:
|
756489
|
| Doc. No
|
:
|
b576451
|
| Main Entry
|
:
|
by Pierre Dustin.
|
| Title & Author
|
:
|
Microtubules\ by Pierre Dustin.
|
| Publication Statement
|
:
|
Berlin, Heidelberg : Springer Berlin Heidelberg, 1978
|
| Series Statement
|
:
|
Microtubules
|
| Page. NO
|
:
|
(xiv, 452 pages 177 illustrations)
|
| ISBN
|
:
|
3540086226
|
|
|
:
|
: 3642964362
|
|
|
:
|
: 9783540086222
|
|
|
:
|
: 9783642964367
|
| Contents
|
:
|
Acknowledgements --; 1 Historical Background --; 1.1 Microtubules (MT) --; 1.2 Colchicine: A Specific MT Poison --; 1.3 Other MT Poisons --; 1.4 Action of Physical Agents on MT --; 1.5 Conclusion --; References --; 2 Structure and Chemistry of Microtubules --; 2.1 Introduction --; 2.2 Shape and Size of MT --; 2.3 Molecular Structure of MT --; 2.4 Chemical Composition --; 2.5 Assembly and Disassembly of MT --; 2.6 Extracellular MT? --; References --; 3 General Physiology of Tubulins and Microtubules --; 3.1 Introduction --; 3.2 Synthesis of Tubulin --; 3.3 Role of Hormones --; 3.4 Role of Cyclic Nucleotides --; 3.5 Role of Nucleating Sites (MTOC) --; 3.6 Disassembly and Reutilization of Tubulin --; 3.7 Differential Sensitivity of MT --; 3.8 Relations of MT With Other Cell Organelles and Structures --; 3.9 Associations and Patterns of MT --; References --; 4 Microtubule Structures: Centrioles, Basal Bodies, Cilia, Axonemes --; 4.1 Introduction --; 4.2 Centrioles --; 4.3 Cilia and Flagella --; 4.4 Other Complex Associations of MT: Axopodia and Axostyles --; References --; 5 Mierotubule Poisons --; 5.1 Introduction --; 5.2 Colchicine --; 5.3 The Catharanthus (Vinca) Alkaloids --; 5.4 Podophyllin and Related Compounds --; 5.5 Griseofulvin --; 5.6 Halothane and Other Anesthetic Drugs --; 5.7 Isopropyl-N-Phenylcarbamate (IPC) --; 5.8 Melatonin --; 5.9 Sulfhydryl Binding Drugs and Metals --; 5.10 Other MT Poisons --; 5.11 Comparison with the Action of Physical Agents and Heavy Water --; References --; 6 Cell Shape --; 6.1 Introduction --; 6.2 MT in Disk-Shaped Blood Cells --; 6.3 Nuclear and Cytoplasmic Shaping in Spermatogenesis --; 6.4 Morphogenesis and Cell Growth --; 6.5 The Shaping of Nerve Cells --; 6.6 Other Relations of MT and Cell Shape in Metazoa --; 6.7 Cell Shape in Protozoa --; 6.8 Cell Shape in Plants --; 6.9 MT with Structural and Mechanical Functions 249 References --; 7 Cell Movement --; 7.1 Introduction --; 7.2 Micro tubules and Microfilaments --; 7.3 An Introductory Note on Mechanisms of Movement Associated With MT --; 7.4 Ciliary Movement --; 7.5 Intracellular Displacements and Motion --; 7.6 Cell Motility and Locomotion --; References --; 8 Secretion, Exo- and Endocytosis --; 8.1 Introduction --; 8.2 Endocrine Secretion --; 8.3 Exocrine Secretion --; 8.4 Leukocytes: Phagocytosis and Exocytosis --; 8.5 Other Cell Activities Related to Secretion or Transport --; References --; 9 Neurotubules: Neuroplasmic Transport, Neurosecretion, Sensory Cells --; 9.1 Introduction --; 9.2 Morphology and General Properties --; 9.3 Experimental Changes of Neurotubules --; 9.4 Neurotubules and Neuroplasmic (“Axonal”) Flow and Transport --; 9.5 Axonal Flow and Neurosecretion --; 9.6 Theories of Neuroplasmic Flow --; 9.7 MT and Sensory Cells --; 9.8 The Intranuclear Rods of Sympathetic Neurons --; References --; 10 The Role of MT in Mitosis --; 10.1 Introduction --; 10.2 Some Aspects of the Evolution of Mitosis --; 10.3 Some Types of Mitosis --; 10.4 Role of MT in Mitotic Movements --; 10.5 Action of Physical Agents and MT Poisons on Mitotic Movements --; 10.6 MT and the Theories of Mitosis --; References --; 11 Pathology and Medicine --; 11.1 Introduction --; 11.2 Colchicine and Gout --; 11.3 Other Therapeutic Uses of Colchicine --; 11.4 Colchicine Poisoning in Man --; 11.5 The Thrombocytopoie tic Action of VCR --; 11.6 The Neurological Toxicity of Catharanthus Alkaloids --; 11.7 Toxicity of MT Poisons Used in Cancer Chemotherapy --; 11.8 Tubulin and MT Pathology --; References --; 12 Outlook --; 12.1 Unity or Diversity? --; 12.2 Microtubule-Associated Proteins --; 12.3 Assembly and Disassembly --; 12.4 Tubulins and MT Poisons --; 12.5 MT and Membranes --; 12.6 MT and Movement --; 12.7 Scaffolding by MT --; 12.8 MT and Evolution --; List of Abbreviations.
|
| Abstract
|
:
|
The author of this remarkably comprehensive review, PIERRE DUSTIN, has performed an invaluable service in bringing to gether in one volume the observations and theory on micro tubules that have accumulated over the last fifteen years. He has understood the magnitude of the task from the beginning and has met it thoroughly and, I must say, courageously. From here on, and for many years to come, young investiga tors, and some not so young, will have a ready reference as they seek to discover what has been done and remains to be done in achieving a better understanding of these important cell components. Since the early 1960's when it became clear that the fila ments (micro tubules) making up the 9 + 2 complex of cilia and flagella were to be found very widely in cells, microtub ules have attracted an ever-increasing amount of attention. Now it is known, as reviewed in this volume, that they influ ence the morphogenesis of anisometry in the shapes of cells and cell extensions; that they function as frames for the intra cellular movement of granules and chromosomes; that they are subject to control in their assembly and disassembly by externally applied substances such as colchicine and cyclic AMP; and that they display abnormalities in their numbers and orientations in transformed (malignant) cells, to mention only a few of their several functions.
|
| Subject
|
:
|
Life sciences.
|
| Subject
|
:
|
Medicine.
|
| LC Classification
|
:
|
QH603.M44B975 1978
|
| Added Entry
|
:
|
Pierre Dustin
|
| |