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" Human Genetics : "
by Friedrich Vogel, Arno G. Motulsky.
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BL
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| Record Number
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759332
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b579303
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| Main Entry
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by Friedrich Vogel, Arno G. Motulsky.
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| Title & Author
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Human Genetics : : Problems and Approaches\ by Friedrich Vogel, Arno G. Motulsky.
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| Edition Statement
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Third, Completely rev. edition
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| Publication Statement
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Berlin, Heidelberg : Springer Berlin Heidelberg, 1997
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| Page. NO
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(lxxii, 851 pages)
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| ISBN
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3662033569
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: 9783662033562
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| Contents
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History of Human Genetics --; Human Genome Sequence and Variation --; Chromosomes --; From Genes to Genomics to Proteomics --; Formal Genetics of Humans: Modes of Inheritance --; Linkage Analysis for Monogenic Traits --; Oligogenic Disease --; Formal Genetics of Humans: Multifactorial Inheritance and Common Diseases --; Lessons from the Genome-Wide Studies for Complex Multifactorial Disorders and Traits --; Epigenetics --; Human Gene Mutation: Mechanisms and Consequences --; Human Hemoglobin --; Human Genetics of Infectious Diseases --; Gene Action: Developmental Genetics --; Cancer Genetics --; The Role of the Epigenome in Human Cancers --; Population Genetic Principles and Human Populations --; Consanguinity, Genetic Drift, and Genetic Diseases in Populations with Reduced Numbers of Founders --; Human Evolution --; Comparative Genomics --; Genetics and Genomics of Human Population Structure --; Genetic Epidemiology --; Pharmacogenetics --; Behavioral Genetics --; The Genetics of Personality --; Mental Retardation and Intellectual Disability --; Genetic Factors in Alzheimer Disease and Dementia --; Genetics of Autism --; The Genetics of Alcoholism and Other Addictive Disorders --; Behavioral Aspects of Chromosomal Variants --; Genetics of Schizophrenia and Bipolar Affective Disorder --; Model Organisms for Human Disorders --; Mouse as a Model for Human Disease --; Caenorhabditis elegans, A Simple Worm: Bridging the Gap Between Traditional And Systems-Level Biology --; Drosophila as a Model for Human Disease --; Human Genetics and the Canine System --; Fish as a Model for Human Disease --; Genetic Counseling and Prenatal Diagnosis --; Gene Therapy --; Cloning in Research and Treatment of Human Genetic Disease --; Genetic Medicine and Global Health --; Genetic Databases --; Databases and Genome Browsers --; Ensembl Genome Browser --; Databases in Human and Medical Genetics.
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| Abstract
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The first two editions of this book, published in 1979 and in 1986, were well re ceived by the scientific community. Translations into Italian, Japanese, and Rus sian suggest that this book was regarded useful in many parts of the world. Mean while, human genetics has seen dramatic developments, and the "molecular revo lution" has attracted thousands of scientists, including many molecular biologists, to this field. About 3700 human genes have already been mapped to chromosomal sites. Many such genes have been cloned, and the various mutations causing dis ease have been identified. Novel mutational mechanisms such as expanded trinu cleotide repeats have been discovered in conditions such as Huntington's disease and the fragile X syndrome of mental retardation. Gene action now can often be elucidated by studying the pathway from gene to phenotype following positional cloning rather than working in the opposite direction, as was customarily done be fore the tools of "new genetics" were available. In an increasing number of genetic diseases, the pathogenic mechanisms have been elucidated with positive conse quences for prevention and treatment. It therefore became necessary to rewrite al most completely major portions of this book. These developments are now making genetics arguably the leading basic science for medicine, as well as a recognized medical speciality. But all these changes do not mean that the entire framework of human genetics had to be reconstructed.
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| Subject
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Human genetics.
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Medicine.
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| LC Classification
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QH431.B947 1997
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| Added Entry
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Arno G Motulsky
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Friedrich Vogel
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