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" New horizons in predictive drug metabolism and pharmacokinetics "
edited by Alan G.E. Wilson.
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BL
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| Record Number
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765017
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b584998
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| Main Entry
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edited by Alan G.E. Wilson.
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| Title & Author
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New horizons in predictive drug metabolism and pharmacokinetics\ edited by Alan G.E. Wilson.
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| Publication Statement
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Cambridge, UK : Royal Society of Chemistry, [, 2016]
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| Series Statement
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RSC drug discovery series.
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| Page. NO
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(xxi, 422 pages .).
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| ISBN
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1782622373
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: 9781782622376
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| Contents
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How physicochemical properties of drugs affect their metabolism and clearance; Role of solubility, permeability and adsorption in drug discovery in development; Models for nonspecific binding and partitioning; Cytochrome P450 mediated drug metabolism; Non-cytochrome P450 enzymes and glucuronidation; Metabolite profiling; Application of humanised and other transgenic models to predict human responses to drugs; Stem cells and drug metabolism; Chemically reactive versus stable drug metabolites: Role in adverse drug reactions; Integrating metabolism and toxicity properties; Metabolomics-based approaches to determine drug metabolite profiles; Drug-drug ineteractions: regulatory and theoretical considerations, and an industrial perspective; Drug-drug interactions: Computational approaches; Induction of hepatic cytochrome P450 enzymes: Importance in drug development and toxicity; Current status and implications of transporters: QSAR analysis method to evaluate drug-drug interactions of human bile salt export pump (ABCB11/BSEP) and prediction of intrahepatic cholestasis risk; Formulation of optimizing bioavailability; Systems pharmacology modelling; Pharmacokinetic-pharmacodynamic modelling in drug development with special reference to oncology;
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| Subject
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Drug development.
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Drugs -- Metabolism.
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Pharmacokinetics.
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| LC Classification
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RM301.55E358 2016
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| Added Entry
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A G E Wilson
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Royal Society of Chemistry (Great Britain)
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