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" The cellular response to the genotoxic insult : "
ed. by Helmut Greim ...
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BL
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| Record Number
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767588
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b587572
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| Main Entry
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ed. by Helmut Greim ...
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| Title & Author
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The cellular response to the genotoxic insult : : the question of threshold for genotoxic carcinogens\ ed. by Helmut Greim ...
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| Publication Statement
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Cambridge RSC Publishing, 2012
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| Series Statement
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Issues in toxicology, 13
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| ISBN
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1849731772
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: 1849732922
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: 9781849731775
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: 9781849732925
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| Notes
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Parallel als Buch-Ausg. erschienen
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| Contents
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Introduction: The rationale for thresholds for genotoxic carcinogens; Part 1. Threshold effects observed in experimental studies: Mechanisms responsible for the chromosome and gene mutations driving carcinogenesis: implications for dose-response characteristics of mutagenic carcinogens; Dose-effect relationships of DANN-reactive liver carcinogens; DNA alkylation and repair after EEMS exposure: Where do the thresholds for mutagenic/clastogenic effects arise? Part 2. Metabolic inactivation of genotoxic reactants: Enzymatic detoxification of endogenously produced mutagenic carcinogens maintaining cellular homeostasis; Phase 2 detoxifying enzymes and anti-oxygen defense mechanisms in the inactivation of genotoxic carcinogens; Part 3. DNA repair: Consequences and Repair of oxidative DNA damage; The plasticity of DNA damage response during cell differentiation: pathways and consequences; Tumor suppressor protein-mediated regulation of base excision repair in response to DNA damage; Part 4. Apoptosis: Survival and death strategies in cells exposed to genotoxin; Different modes of cell death induced by DNA damage; Transcriptional inhibition by DNA damage as a trigger of cell death; Part 5. Epigenetic mechanisms: The interplay between epigenetics and Gap junctionional intercellular communication; Index
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| LC Classification
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RA1224.3E339 2012
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| Added Entry
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Helmut Greim
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