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" Enzyme Chemistry : "
edited by Colin J. Suckling.
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BL
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| Record Number
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772720
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b592714
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| Main Entry
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edited by Colin J. Suckling.
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| Title & Author
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Enzyme Chemistry : : Impact and applications\ edited by Colin J. Suckling.
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| Edition Statement
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Second edition
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| Publication Statement
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Dordrecht : Springer Netherlands, 1990
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| Page. NO
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(400 pages)
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| ISBN
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9400918321
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: 9401073171
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: 9789400918320
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: 9789401073172
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| Contents
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Contributors --; Preface --; 1 Infant Enzyme Chemistry --; 2 The Mechanistic Basis of Enzyme Catalysis --; 2.1 The mechanistic approach --; 2.2 Concepts of catalysis --; 2.3 Describing a mechanism --; 2.4 Kinetics: the measure of catalysis --; 2.5 Stereochemistry and specificity --; 2.6 Stereochemistry and mechanism --; 2.7 Entropy and enzymic catalysis --; 2.8 Acid-base catalysis --; 2.9 Linear free-energy relationships and enzymic reactions --; 2.10 Enzymic efficiency --; 2.11 Examples of intramolecular catalysis --; 2.12 Transition state analogues --; 2.13 Multiple binding sites --; 2.14 Biomimetic chemistry --; 2.15 Conclusion --; References --; 3 Chemical Models of Selected Coenzyme Catalyses --; 3.1 Introduction --; 3.2 Model investigations of nicotinamide coenzymes --; 3.3 Flavin catalyses --; 3.4 Catalyses relating to vitamin B1 and analogues --; 3.5 Pyroxidal catalyses --; 3.6 Catalyses of thiol coenzymes --; 3.7 Conclusion --; References --; 4 Selectivity in Synthesis --; Chemicals or Enzymes? --; 4.1 Introduction --; 4.2 Problems overcome --; 4.3 Logic and analogy in the synthetic uses of enzymes and micro-organisms --; 4.4 Enzymes and chemical reagents in 'competition' --; 4.5 Late-stage functional-group modification --; 4.6 Biomimetic chemistry in synthesis --; 4.7 Enzymes in organic solvents --; 4.8 Advances in protein chemistry and molecular biology --; 4.9 Conclusions --; References --; 5 Enzymes As Targets for Drug Design --; 5.1 Introduction --; 5.2 Case studies in drug discovery --; 5.3 Recent developments and their application to inhibitor design --; References --; 6 The Impact of Metal Ion Chemistry on Our Understanding of Enzymes --; 6.1 Introduction and general chemical principles --; 6.2 The transition elements iron and copper --; 6.3 Transition metal ions --; 6.4 Main group elements --; 6.5 Some toxic metals --; 6.6 Metal ions as drugs --; 6.7 Modern physical methods --; 6.8 Conclusions 262 References --; 7 The Enzymology of The Biosynthesis of Natural Products --; 7.1 Introduction --; 7.2 Recent advances in the study of biosynthetic enzymes --; 7.3 Terpenoid cyclases --; 7.4 Problems and prospects 298 References --; 8 Enzymes in The Food Industry --; 8.1 Introduction --; 8.2 Amylases and starch hydrolysis --; 8.3 Enzymes acting on glucose and oligosaccharides --; 8.4 The plant cell wall and its breakdown --; 8.5 Industrial applications of plant cell wall degrading enzymes --; 8.6 Exogenous enzymes in cheese making --; 8.7 Conclusions 348 --; References --; 9 Enzymology And Protein Chemistry in The Wider Area of Biology --; 9.1 Introduction --; 9.2 Studies of enzymes by techniques of molecular biology --; 9.3 Theoretical treatments of enzyme catalysis --; 9.4 Protein structure, homology and genetic relationships --; 9.5 Interactions between proteins and DNA --; 9.6 Novel catalysts --; 9.7 Apolipoprotein B --; 9.8 Receptors --; 9.9 Conclusions 372 --; References.
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| Subject
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Analytical biochemistry.
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| Subject
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Chemistry.
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| LC Classification
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QP601.E358 1990
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| Added Entry
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C J Suckling
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