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" Nuclear factor kB : "
edited by Rudi Beyaert.
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BL
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| Record Number
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774205
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b594199
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| Main Entry
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edited by Rudi Beyaert.
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| Title & Author
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Nuclear factor kB : : regulation and role in disease\ edited by Rudi Beyaert.
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| Publication Statement
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Dordrecht : Springer Netherlands : Imprint : Springer, 2003
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| Page. NO
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(XI, 426 pages)
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| ISBN
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9401001634
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: 9401039836
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: 9789401001632
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: 9789401039833
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| Contents
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Activators and Target Genes of Rel/NF-?B Transcription Factors --; From Bench to Bedside --; NF-?B Activation by Tumor Necrosis Factor and Interleukin-1 --; NF-?B Activation by CARD Proteins --; Viruses as Intruders in the Rel/NF-?B Signaling Pathway --; The I?B Kinase (IKK) Complex --; The Role of Ubiquitin in NF-?B Signaling --; New Insights into the Regulation of NF-?B --; Roles for Phosphorylation and Acetylation of NF-?B Subunits --; The Structural Biology of NF-?B --; Tools to Interfere with NF-?B Activation --; Regulation of NF-?B by Glucocorticoids --; Genetic Analysis of NF-?B-dependent Signaling Pathways in Mammalian Cells --; Delineation of NF-?B Signaling by Gene Targeting --; The Role of NF-?B in Inflammatory Diseases --; NF-?B in Genetic Disorders --; NF-?B in the Vascular System --; NF-?B in T-lymphocyte Biology --; NF-?B in the Nervous System --; NF-?B in Oncogenesis and as a Target for Cancer Therapy --; Control of Immunity by Rel Proteins in Drosophila.
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| Abstract
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The transcription factor NF-kappaB and the signaling pathways regulating its activity constitute a paradigm of membrane to nucleus communication. NF-kappaB is central to a number of cellular functions including cell proliferation, apoptosis, and cellular differentiation. This transcription factor also plays essential roles in innate and acquired immunity, and its deregulation leads to important human diseases such as inflammation and cancer. Therefore NF-kappaB, together with the signaling pathways leading to its activation, constitute an attractive therapeutic target. This book is the first to review and synthesize our knowledge on this interesting transcription factor. It will be of great interest for those entering or already actively working in the NF-kappaB field, as well as a valuable reference for students, established researchers, or clinicians with wider interests in the fields of molecular cell biology and biomedicine.
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| Subject
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Immunology.
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Medicine.
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Oncology.
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| LC Classification
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QP552.N46E358 2003
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| Added Entry
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Rudi Beyaert
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