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" Asymmetric Synthesis "
edited by R. Alan Aitken, S. Nicholas Kilényi.
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BL
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| Record Number
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774843
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b594838
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| Main Entry
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edited by R. Alan Aitken, S. Nicholas Kilényi.
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| Title & Author
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Asymmetric Synthesis\ edited by R. Alan Aitken, S. Nicholas Kilényi.
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| Publication Statement
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Dordrecht : Springer Netherlands, 1992
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| Page. NO
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(xiii, 233 pages)
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| ISBN
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9401113467
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: 9789401113465
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| Contents
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1 Chirality --; 1.1 The phenomenon of chirality --; 1.2 The biological significance of chirality: the need for asymmetric synthesis --; 1.3 The selective synthesis of enantiomers --; 1.4 The enantiomeric purity of natural products --; 1.5 The stereogenic unit and types of chiral compound --; 1.6 Centrally chiral compounds of carbon and silicon --; 1.7 Centrally chiral compounds of nitrogen and phosphorus --; 1.8 Centrally chiral compounds of sulphur --; 1.9 Axially chiral compounds --; 1.10 Chiral molecules with more than one stereogenic unit: diastereomers --; 1.11 The selective synthesis of diastereomers --; 1.12 Prochirality: enantotopic and diastereotopic groups --; 1.13 Absolute configuration 20 Reference and notes --; 2 The description of stereochemistry --; 2.1 Compounds with one stereogenic centre --; 2.2 Axially chiral compounds --; 2.3 Compounds with more than one stereogenic unit --; 2.4 The topicity of enantioselective reactions --; 2.5 The relative topicity of diastereoselective reactions --; 2.6 Further points on correct terminology --; References and notes --; 3 Analytical methods: determination of enantiomeric purity --; 3.1 Polarimetric methods --; 3.2 Gas chromatography methods --; 3.3 Liquid Chromatographic methods --; 3.4 NMR spectroscopy --; 3.5 Concluding remarks --; References and notes --; 4 Sources and strategies for the formation of chiral compounds --; 4.1 Chiral starting materials --; 4.2 Methods for the formation of chiral compounds --; 4.3 Mechanistic considerations --; References and notes --; 5 First- and second-generation methods: chiral starting materials and auxiliaries --; 5.1 Non-stereodifferentiating methods --; 5.2 First-generation methods --; 5.3 Second-generation methods: nucleophiles bearing a chiral auxiliary --; 5.4 Electrophiles bearing chiral auxiliaries --; 5.5 Chiral auxiliaries in concerted reactions --; References --; 6 Third- and fourth-generation methods: asymmetric reagents and catalysts --; 6.1 C --; C bond-forming reactions --; 6.2 Chiral acids and bases --; 6.3 Asymmetric oxidation methods --; 6.4 Asymmetric reduction, double bond isomerisation and hydroboration --; 6.5 Enzymatic and microbial methods --; References --; 7 Asymmetric total synthesis --; 7.1 First-generation methods --; 7.2 Second-generation methods --; 7.3 Third-generation methods --; 7.4 Fourth-generation methods --; References.
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| Subject
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Science (General)
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| LC Classification
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QD262.E358 1992
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| Added Entry
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R Alan Aitken
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S Nicholas Kilényi
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