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" Side-Effects of Anti-Inflammatory Drugs 3 "
edited by K.D. Rainsford, G.P. Velo.
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BL
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775154
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b595149
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| Main Entry
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edited by K.D. Rainsford, G.P. Velo.
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| Title & Author
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Side-Effects of Anti-Inflammatory Drugs 3\ edited by K.D. Rainsford, G.P. Velo.
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| Publication Statement
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Dordrecht : Springer Netherlands : Imprint : Springer, 1992
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| Series Statement
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Inflammation and drug therapy series, 5.
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(400 pages)
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| ISBN
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9401053251
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: 9401129827
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: 9789401053259
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: 9789401129824
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| Contents
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Section I: Epidemiology --; 1 The gastrointestinal toxicity of the non-steroidal anti-inflammatory drugs --; 2 The value of the case-control approach for the evaluation of the risk of upper gastrointestinal bleeding associated with the previous use of non-steroidal anti-inflammatory drugs --; 3 Liver toxicity of antipyretic drugs in conjunction with measles infections --; 4 Non-steroidal anti-inflammatory drugs and hypersensitivity reactions --; 5 What can a spontaneous reporting system teach about side-effects of anti-inflammatory drugs? --; 6 Adverse reactions to NSAIDs: consecutive evaluation of 30 000 patients in rheumatology --; Section II: Gastrointestinal Tract: Clinical Aspects --; 7 The evaluation of acute gastrointestinal toxicity of NSAIDs in phase I clinical trials: a critical appraisal --; 8 The ulcerogenic and anti-haemostatic effects of NSAIDs in the gut --; 9 What role does Helicobacter pylori infection play in NSAID-associated gastric inflammation? --; 10 Endoscopic evaluation of NSAID ulceration --; 11 Food antigen absorption in rheumatoid arthritis: effect of acetylsalicylic acid --; 12 Intestinal mucosal permeability in inflammatory rheumatic diseases --; 13 Comparison of effects on gastrointestinal blood loss and gastric mucosal appearance of piroxicam-?-cyclodextrin, piroxicam and placebo --; Section III: Gastrointestinal Tract: Prevention Of Adverse Effects --; 14 Mechanisms of gastrointestinal ulceration from non-steroidal anti-inflammatory drugs: a basis for use and development of protective agents --; 15 Novel strategies of gastric and duodenal mucosal protection against NSAID injury: role of protease inhibitors, muscle relaxants and growth factors --; 16 The role of misoprostol in preventing NSAID-induced damage to the gastrointestinal tract --; 17 Possible factors involved in the protective effects of interleukin-1 in aspirin- and indomethacin-induced gastric damage --; 18 Prevention and treatment of NSAID-gastroduodenal damage: the role of H2-receptor antagonists --; 19 Omeprazole in the prevention and therapy of gastroduodenal lesions on NSAID therapy --; 20 Sucralfate in the prevention of NSAID-induced gastric ulceration --; 21 Ketotifen --; a novel approach to the prevention of damage in the gastrointestinal tract --; Section IV: Hepatotoxicity --; 22 The hepatotoxicity of non-steroidal anti-inflammatory drugs --; 23 Paracetamol (acetaminophen) bioactivation by liver microsomes --; its role in hepatotoxicity --; 24 Increased liver toxicity of diclofenac by paracetamol: results and possible mechanisms --; 25 Effects of NSAIDs on liver microsomal mono-oxygenase system and products of oxidative metabolism of arachidonic acid --; 26 Hepatitis due to non-steroidal anti-inflammatory drugs (NSAIDs) --; Section V: Nephrotoxicity --; 27 Current status of nephrotoxicity caused by non-steroidal anti-inflammatory drugs --; 28 Are oral prostaglandins effective in preventing nephrotoxicity from NSAIDs and cyclosporin? --; Section VI: Specific Issues Related To Side-Effects --; 29 Aspirin and Reye's syndrome --; 30 Antirheumatic drug therapy in the elderly --; 31 NSAIDs and human cartilage metabolism --; 32 Non-steroidal anti-inflammatory drugs and the augmented lipoxygenase pathway: conceivable impact on joint conditions --; 33 Therapeutic potential of 5-lipoxygenase inhibitors: the discovery and development of MK-886, a novelmechanism leukotriene inhibitor --; 34 Mechanisms of rash formation and related skin conditions induced by non-steroidal anti-inflammatory drugs --; Section VII: Antirheumatic And Immunoregulatory Agents --; 35 Cyclosporin: clinical efficacy and toxicity in patients with rheumatoid arthritis --; 36 Risk factors and risk-benefit problems in the use of DMARDs --; 37 Gold toxicity: chemical, structural, biological and clinical experimental issues --; Section VIII: Extended Poster Presentations --; 38 A review of interaction studies between non-steroidal anti-inflammatory drugs and HTreceptor antagonists or prostaglandin analogues --; 39 Influence of different anti-inflammatory substances on ethanol- and indomethacin-induced gastrointestinal mucosal damage --; 40 The role of copper in preventing gastric damage by acetylsalicylic acid --; 41 Effect of NSAID therapy on plasma, whole blood cell (BC), and 24h urine zinc in patients with rheumatoid arthritis (RA).
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| Abstract
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This book brings together physicians, scientists and those concerned with the production and use of anti-inflammatory drugs to discuss basic issues affecting all aspects of side-effects, including their detection and treatment. <br/> The chapters cover a wide variety of topics including the epidemiology, clinical and experimental aspects of side-effects in the GI tract, liver, kidney, cartilage, bone and skin as well as the problems associated with the newer range of disease-modifying anti-rheumatic drugs such as methotrexate and cyclosporin. <br/> This book will be of interest to all those who develop and use anti-inflammatory analgesic drugs, from basic scientists to clinicians. It contains papers presented at the Third International meeting on 'Side-Effects of Anti-Inflammatory and Analgesic Drugs' held in Verona, Italy, 8-11 May 1991. <br/>
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Anti-inflammatory agents -- Side effects -- Congresses.
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| Subject
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Anti-inflammatory agents -- Side effects.
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| Added Entry
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G P Velo
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K D Rainsford
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