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" Immunosuppression under Trial : "
edited by P. Cochat, J. Traeger, C. Merieux, M. Derchavane.
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BL
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| Record Number
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775371
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b595366
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| Main Entry
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edited by P. Cochat, J. Traeger, C. Merieux, M. Derchavane.
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| Title & Author
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Immunosuppression under Trial : : Proceedings of the 31st Conference on Transplantation and Clinical Immunology, 3-4 June, 1999\ edited by P. Cochat, J. Traeger, C. Merieux, M. Derchavane.
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| Publication Statement
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Dordrecht : Springer Netherlands, 1999
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| Series Statement
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Transplantation and Clinical Immunology, Symposia Fondation Marcel Mérieux, 31.
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| Page. NO
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(ix, 179 pages)
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| ISBN
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9401146438
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: 9789401146432
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| Contents
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1: Setting the stages in clinical trials --; 1. Current results as reference for future improvements in immunosuppression --; 2. Rationale of clinical trials from the physician --; 3. Minimal standards for reporting clinical trial results in transplantation --; 4. Methodological approach of clinical trials for renal transplantation --; 2: Is acute rejection an appropriate surrogate marker? --; 5. Surrogate end-points for clinical trials in renal transplantation --; 6. Is acute rejection an appropriate surrogate marker for clinical trials in liver transplantation? --; 7. The success of clinical immunosuppressive trials in heart transplantation: the early detection of acute rejection --; 3: Towards long-term end-points --; 8. Factors influencing long-term allograft survival --; 4: Can we minimize the long-term side effects? --; 9. Patients' appraisal of side effects in quality of life assessments of immunosuppressive regimens --; 10. Cardiovascular complications after renal transplantation --; 11. Strategies to minimize nephrotoxicity associated with calcineurin inhibitors --; 12. Diabetogenic effect of immunosuppressive drugs --; 13. Can we minimize long-term side effects of immunosuppressive drugs on lipid metabolism? --; 14. Can we minimize the long-term side effects of immunosuppressive drugs in pediatric patients? --; 5: Strategies --; 15. Induction therapy --; 16. Effect of long-term immunosuppression in kidney-graft recipients on cancer incidence: randomised comparison of two cyclosporin regimens --; 17. Immunosuppression in composite tissue transplantation --; 18. The search for immunosuppressive synergy --; 19. Economic analysis of immunosuppression in transplantation: a review of recent studies in liver and kidney transplantation --; 6: Clinical trials for at-risk situations --; 20. Questions raised by the exclusion of 'at risk' conditions from current trials in organ transplantation --; Name index.
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| Abstract
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Immunosuppression in solid organ transplantation is currently experiencing a worldwide revival since new drugs are now available and others are under development. In order to contribute to the design of future strategies, a critical approach of surrogate endpoints is given and long-term side effects are analysed, together with the impact of non-compliance, quality-of-life and economical parameters. In this book, international specialists have set up the scientific rationale and provided new bases for further immunosuppressive strategies.
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| Subject
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Immunology.
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Medicine.
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Nephrology.
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| LC Classification
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RC581.2E358 1999
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C Merieux
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J Traeger
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M Derchavane
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P Cochat
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