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" Tracer Methods for in Vivo Kinetics : "
Reginald Shipley
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BL
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| Record Number
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775744
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b595740
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| Main Entry
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Reginald Shipley
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| Title & Author
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Tracer Methods for in Vivo Kinetics : : Theory and Applications.\ Reginald Shipley
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| Publication Statement
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Saint Louis : Elsevier Science, 2014
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(254 pages)
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| ISBN
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0323158900
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: 9780323158909
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| Contents
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Front Cover; Tracer Methods for in Vivo Kinetics: Theory and Applications; Copyright Page; Table of Contents; Preface; List of Symbols; CHAPTER 1. Compartment Analysis: A Single Pool, Real or by Lumping; Compartments or Pools; Single-Pool Kinetics; Estimation of Size and Turnover Rate of Two Pools Lumped as if One; Excretion of Drugs; CHAPTER 2. Compartment Analysis: Two-Pool Open Systems; Multiple-Compartment Analysis; Analysis of an Interchanging System; Solution by Sampling Labeled Pool a; Solution by Sampling Secondary Pool b Alone; A Noninterchanging System; Precautions and Limitations. CHAPTER 3. Compartment Analysis: Three-Pool Open SystemsA Completely Interchanging System; Three Compartments Not Interchanging Completely; Dissection of Rates; Prediction of an Explicit Solution; Prediction of Model; CHAPTER 4. Compartment Analysis: Four or More Pools; Four Pools; Joining Subsystems; Errors and False Inferences in Curve Analysis; Analysis by Computer; CHAPTER 5. Stochastic Analysis: The Stewart-Hamilton Equation; Meaning of "Stochastic"; The Stewart-Hamilton Equation; The Stewart-Hamilton Equation When Rate Is for Mass. CHAPTER 6. Stochastic Analysis: Rates of Production, Disposal, Secretion, and Conversion Clearance; Production (or Disposal) Rate of Individual Species; Calculation of Local Output Rate; Sampling Two Pools; Rate Analysis by SA of Pooled Output; Clearance; Limitations; CHAPTER 7. Stochastic Analysis: Mean Transit Time, Mass, Volume; Concept of Mean Time; Mean Sojourn Time; All Input to Labeled Pool-Interrelated Formulas; CHAPTER 8. Closed Systems, Cumulative Loss, Sinks; Closed Systems; Cumulative Loss; Sink Effect; CHAPTER 9. Constant Infusion of Tracer. Estimation of Rate without Compartment AnalysisCompartment Analysis; Clearance; CHAPTER 10. Nonsteady State; Meaning of Nonsteady State; A Single Pool; Complex Systems; CHAPTER 11. Circulation Rate Measured by Tissue Saturation or Desaturation; A Single Homogeneous Tissue; A Nonhomogeneous Organ; External Monitoring; CHAPTER 12. Various Approximations from Curves; Behavior of Primary Labeled Pool; Iodide Transport; Impulse Analysis; APPENDIX I: Derivation of the Formula for Simple Exponential Loss; APPENDIX II: Mathematical Solution of Multicompartment Models in Steady State. A. An Open Three-Pool SystemB. An Open Four-Pool System; C. Change in Equations When Channels or Pools Are Eliminated; D. Special Case, One-Way Flow, Equal-Sized Pools; APPENDIX III: Relation of a Rate Ratio to Vertical Shift in tmax; APPENDIX IV: Deconvolution by Numerical Sequence Approximation; APPENDIX V: Some Definite Integrals and Derivatives; References; Index.
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| Abstract
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Tracer Methods for In Vivo Kinetics: Theory and Applications summarizes and evaluates the variety of working formulas in applying tracer methods for kinetic studies in vivo. This book discusses the basic concepts, derives the important equations, and evaluates each working formula to ensure its proper application within the set of experimental conditions available. Organized into 12 chapters, this book starts with an overview of tracers such as radioactive atoms. This text then discusses the errors inherent in treating a two-pool system as though it were one pool. Other chapters describe h.
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Medicine -- Mathematics.
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Radioisotopes in physiology.
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| LC Classification
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QP521.R445 2014
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| Added Entry
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Reginald Shipley
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