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" Cell culture methods for in vitro toxicology "
edited by Glyn N. Stacey, Alan Doyle and Margherita Ferro.
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BL
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| Record Number
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776600
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b596597
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| Main Entry
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edited by Glyn N. Stacey, Alan Doyle and Margherita Ferro.
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| Title & Author
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Cell culture methods for in vitro toxicology\ edited by Glyn N. Stacey, Alan Doyle and Margherita Ferro.
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| Publication Statement
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Dordrecht ; London : Kluwer Academic, [, 2001] ©2001
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| Page. NO
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(ix, 153 pages) : illustrations
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| ISBN
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9401709963
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: 9789401709965
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| Notes
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Reprinted from Cell biology and toxicology, Vol. 17, Issues 4 & 5, 2001.
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| Contents
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Standardisation for In Vitro toxicity test / Margherita Ferro and Alan Doyle --; Application of cell cultures to toxicology / Ian Freshney --; Immortalisation of primary cells / Glyn Stacey and Caroline MacDonald --; Safety considerations for In Vitro toxicology testing / Bruce Jones and Glyn Stacey --; The drug metabolizing enzymatic system and the experimental tools used for In Vitro toxicology for metabolic studies / Emanuela Testai --; Cell culture models for hepatotoxicology / Thierry Battle and Glyn Stacey --; Intestinal cell culture models : applications of toxicology and pharmacology / Yula Sambruy [and others] --; Cell culture models for neurotoxicology / Glyn Stacey and [Barbara] Viviani --; Recombinant cell lines for stress reporter assays / Michel Fischbach and Peter Bromley.
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| Abstract
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Cell Culture Methods for in vitro Toxicology introduces the reader to a range of techniques involved in the use of in vitro cell culture in toxicological studies. It deals with major cell types studied in the field of toxicology and will be useful for anyone wishing to start work with animal cell cultures or to refresh their knowledge relating to in vitro cell models. Fundamental chapters deal with the general biology of cytotoxicity and cell immortalisation these are key issues for in vitro systems addressing the `3Rs' principle. Up-to-date overviews deal with the use of cells from liver, brain and intestine. In addition, biochemical analysis of cell responses, biotransformation pathways in cells and recombinant approaches to the early detection of cell stress are also covered in detail. Prominent features of in vitro technologies also include regulation, biosafety and standardisation. Dedicated chapters deal with these issues in a practical way in order to lead the reader to the right source of information. This book provides an up-to-date, informative and practical review of cell culture methods for in vitro toxicology. It will be of equal benefit to students and experienced toxicologists with little experience of in vitro cell culture.
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| Subject
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Cell culture.
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| Subject
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Cells, Cultured -- drug effects.
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Toxicity testing -- In vitro.
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| LC Classification
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RA1194.4.I5E358 9999
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| Added Entry
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A Doyle
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G Stacey
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Margherita Ferro
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| Parallel Title
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Cell biology and toxicology.
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