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" Brain diseases and metalloproteins "
edited by David R. Brown.
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BL
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| Record Number
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777258
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b597260
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| Main Entry
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edited by David R. Brown.
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| Title & Author
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Brain diseases and metalloproteins\ edited by David R. Brown.
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| Publication Statement
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Singapore : Pan Stanford Pub, 2013
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| ISBN
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9789814316019
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: 9789814364072
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: 9814316016
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: 981436407X
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| Contents
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Introduction David R. BrownBrain DiseasesMetalloproteinsA Possible Key Role for Redox-Active Metal Ions and Soluble Oligomers in Neurodegenerative Disease Brian J. Tabner, Susan Moore, Jennifer Mayes, and David AllsopSummaryIntroduction to the ProteopathiesMutations in Genes Associated with Protein Processing and Aggregation Cause Inherited Forms of ProteopathyThe Toxic Eff ects of Protein Oligomers The Generation of Hydrogen Peroxide by Ass Other Aggregating Protein Systems Mechanism of Hydrogen Peroxide Formation and Ass Oxidation Concluding Comments Modelling of the Metal Binding Sites in Proteins Involved in Neurodegeneration Ewa Gralka, Daniela Valensin, Maurizio Remelli, and Henryk KozlowskiIntroductionPeptides as Models for Unstructured Protein Interactions with Metal IonsStructural Approach to Metal-Peptide Interactions (Role of His as the Metal Ion Binding Site)Thermodynamic and Speciation StudiesImpact of Metal Ions on Prion Protein Fibril FormationImpact of Metal-Peptide Interaction on Oxidative StressMammalian Metallothioneins Duncan E. K. Sutherland and Martin J. StillmanMetallothioneinTechniques for Studying MetallothioneinsMT-1 and MT-2: Inducible MetallothioneinsMT-3: A Central Nervous System MetallothioneinCopper Transporting P-Type ATPases in the Brain Sharon La Fontaine, James Camakaris, and Julian MercerATP7A in the BrainATP7B in the BrainConclusionRole of the Amyloid Precursor Protein and Copper in Alzheimer's Disease Loredana Spoerri, Kevin J. Barnham, Gerd Multhaup and Roberto CappaiThe Amyloid Precursor ProteinCopper PhysiologyCopper and Alzheimer's DiseaseAPP, Copper and Alzheimer's DiseaseAPP Copper Binding Domain (CuBD)ConclusionsRole of Aluminum and Other Metal Ions in the Pathogenesis of Alzheimer's Disease Silvia Bolognin and Paolo ZattaAlzheimer's Disease The Amyloid Cascade and Oligomer Hypothesis Metal Dysmetabolism in AD The Role of Metal Ions in the Aggregation and Toxicity of Ass Ass and Cell Membranes Amyloid Metal Complexes and Ca ConclusionPrion Diseases, Metals and Antioxidants Paul Davies and David R. BrownThe Transmissible Spongiform EncephalopathiesThe Prion ProteinPrP and Copper Binding The Implications of Copper Binding Other MetalsMetals and Aggregation Changes in Brain Metals PrP Survival in the Environment Conclusion Emerging Role for Copper-Bound -Synuclein in Parkinson's Disease Etiology Heather R. Lucas and Jennifer C. LeeIntroductionInteraction of Copper(II) and -Synuclein Metal-Catalysed Protein Oxidation ConclusionInteractions of -Synuclein with Metal Ions: New Insights into the Structural Biology and Bioinorganic Chemistry of Parkinson's Disease Andres Binolfi and Claudio O. FernandezIntroductionInteraction of AS with Cu(II) IonsInteraction of AS with Other Divalent Metal IonsStructural Details Behind the Specificity of AS-Cu(II) InteractionsConclusions and Future Perspectives An Attempt to Treat Amyotrophic Lateral Sclerosis by Intracellular Copper Modification Using Ammonium Tetrathiomolybdate and/or Metallothionein: Fundamentals and Perspective 367 Shin-Ichi Ono, Ei-Ichi Tokuda, Eriko Okawa, and Shunsuke WatanabeIntroductionCauses of ALSCharacterization of G93A Mutant SOD1 MouseMetallothionein, Copper Ions and ALSCellular Damage by Copper OverloadTherapeutic Strategy in Mutant SOD1 Mice Based on "Intracellular Cu Dysregulation" Hypothesis: Intracellular Copper Removal Using Ammonium TetrathiomolybdateTherapeutic Strategy in Mutant SOD1 Mice Based on "Intracellular Cu Dysregulation" Hypothesis: Intracellular Copper Modification Using a Metallothionein-I IsoformConclusionIndex
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| Subject
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Brain -- Diseases.
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Metalloproteins.
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Metallproteide
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| LC Classification
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RC386.E358 2013
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| Added Entry
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David R Brown
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