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" Metathesis in Natural Product Synthesis : "
Janine Cossy
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BL
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| Record Number
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777926
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b597935
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| Main Entry
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Janine Cossy
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| Title & Author
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Metathesis in Natural Product Synthesis : : Strategies, Substrates and Catalysts.\ Janine Cossy
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| Publication Statement
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Hoboken : John Wiley & Sons, 2011
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(414 pages)
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| ISBN
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3527629637
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: 9783527629633
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| Contents
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Cover; Half Title page; Title page; Copyright page; Foreword; Preface; List of Catalysts; List of Contributors; Abbreviations; Chapter 1: Synthesis of Natural Products Containing Medium-size Carbocycles by Ring-closing Alkene Metathesis; 1.1 Introduction; 1.2 Formation of Five-membered Carbocycles by RCM; 1.3 Formation of Six-membered Carbocycles by RCM; 1.4 Formation of Seven-membered Carbocycles by RCM; 1.5 Formation of Eight-membered Carbocycles by RCM; 1.6 Formation of Nine-membered Carbocycles by RCM; 1.7 Formation of 10-membered Carbocycles by RCM; 1.8 Conclusion; References Chapter 2: Natural Products Containing Medium-sized Nitrogen Heterocycles Synthesized by Ring-closing Alkene Metathesis2.1 Introduction; 2.2 Five-membered Nitrogen Heterocycles; 2.3 Six-membered Nitrogen Heterocycles; 2.4 Seven-membered Nitrogen Heterocycles; 2.5 Eight-membered Nitrogen Heterocycles; 2.6 Conclusion; References; Chapter 3: Synthesis of Natural Products Containing Medium-size Oxygen Heterocycles by Ring-closing Alkene Metathesis; 3.1 Introduction; 3.2 General RCM Approaches to Medium Rings; 3.3 Laurencin; 3.4 Eunicellins/Eleutherobin; 3.5 Helianane; 3.6 Octalactin A 3.7 Microcarpalide and the Herbarums3.8 Marine Ladder Toxins; 3.9 Conclusion; Acknowledgments; References; Chapter 4: Phosphorus and Sulfur Heterocycles via Ring-closing Metathesis: Application in Natural Product Synthesis; 4.1 Introduction; 4.2 Synthesis and Reactivity of Sultones Derived from RCM; 4.3 Total Synthesis of the Originally Proposed Structure of (±)-Mycothiazole; 4.4 Synthesis and Reactivity of Phosphates from RCM; 4.5 Applications of Phosphate Tethers in the Synthesis of Dolabelide C; 4.6 Conclusion; Acknowledgment; References Chapter 5: Synthesis of Natural Products Containing Macrocycles by Alkene Ring-closing Metathesis5.1 Introduction; 5.2 Organization of the Chapter; 5.3 Macrocyclic Polyketides; 5.4 Terpenoids; 5.5 Macrocycles of Amino Acid Origin; 5.6 Macrocyclic Glycolipids; 5.7 Conclusions and Outlook; References; Chapter 6: Synthesis of Natural Products and Related Compounds Using Ene-Yne Metathesis; 6.1 Introduction; 6.2 Synthesis of Natural Products and Related Compounds Using Ene-yne Metathesis; 6.3 Synthesis of Natural Products and Related Compounds Using Ene-yne Cross-metathesis (CM) 6.4 Synthesis of Natural Products Using Skeletal ReorganizationReferences; Chapter 7: Ring-closing Alkyne Metathesis in Natural Product Synthesis; 7.1 Introduction; 7.2 Alkyne Metathesis; 7.3 Ring-closing Alkyne Metathesis; 7.4 Applications of RCAM in Natural Product Synthesis; 7.5 Conclusions; References; Chapter 8: Temporary Silicon-Tethered Ring-Closing Metathesis Reactions in Natural Product Synthesis; 8.1 Introduction; 8.2 Temporary Silicon-Tethered Ring-Closing Metathesis Reactions; 8.3 Conclusions and Outlook; Acknowledgments; References
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| Abstract
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Emphasizing the impact of metathesis in natural product synthesis through the different types of key reactions, this is a comprehensive view of a hot topic. Written by top international authors, this ready reference is clearly structured and packed with important information, including representative experimental procedures for practical applications. A real must-have for anyone working in natural product synthesis.
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| Subject
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Metathesis (Chemistry)
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Natural products -- Synthesis.
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| LC Classification
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QD281.M48J365 2011
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| Added Entry
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Christophe Meyer
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Janine Cossy
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Robert H Grubbs
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S Arseniyadis
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