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" Droperidol "
Casimir A Janicki
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BL
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| Record Number
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786467
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b606482
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Casimir A Janicki
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| Title & Author
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Droperidol\ Casimir A Janicki
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| ISBN
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9780122608070
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| Abstract
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This chapter discusses droperidol. It is white to light tan, odorless crystalline powder. The differential scanning calorimetry (DSC) of droperidol is discussed in this chapter. A melting endotherm is observed at 421K using a temperature program of 10˚/minute. The DSC shows different melting peaks for the other polymorphic forms. Although droperidol is sensitive to heat and light, it is stable for up to 5 years when stored in the dark at room temperature. Droperidol is slightly hygroscopic. When droperidol was refluxed overnight in 1M hydrochloric acid, it was found to undergo complete hydrolysis. The specific ultraviolet assay method for droperidol, described, is the preferred assay. The assay is modified slightly when the dosage form contains parabens. After the droperido1 is extracted into citric acid, the citric acid is washed with diethyl ether. This removes any ultraviolet (UV) interferences in the citric acid due to the parabens.
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Casimir A Janicki
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Roger K Gilpin
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