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" The actin cytoskeleton, membrane lipid microdomains, and T cell signal transduction "
S Celeste Posey Morley
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BL
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| Record Number
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786506
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b606521
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| Main Entry
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S Celeste Posey Morley
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| Title & Author
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The actin cytoskeleton, membrane lipid microdomains, and T cell signal transduction\ S Celeste Posey Morley
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| ISBN
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9780120224777
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| Abstract
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The adaptive immune system is regulated in large part by the CD4 + helper T lymphocytes. Antigen-presenting cells (APCs) display peptide antigens in the context of major histocompatibility complex (MHC) molecules on their surface that can bind to the T cell receptor (TCR) on antigen-specific T cells. When bound, the TCR complex generates a complicated array of intracellular signals. The integrated outcome of these signals depends on the cellular context in which the signal is received and may result in T cell activation, anergy, or apoptosis. A signal is generated when a peptide in the context of an MHC molecule engages the TCR complex. This binding interaction sets off a cascade of membrane proximal events in T cell signal transduction that include activation (or inactivation) of enzymes (kinases and/or phosphatases), phosphorylation of substrates, and recruitment of adapter proteins that enable the formation of large signaling complexes. These early signaling events of tyrosine phosphorylation and protein-protein interactions enable the propagation of downstream signals that lead to calcium flux and the activation of downstream kinases, such as mitogen-activated protein kinases (MAPK).
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| LC Classification
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QR181.S345 9999
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| Added Entry
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Barbara E Bierer Affiliation: Department of Pediatrics, Harvard Medical School, Boston, Massachusetts USA
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S Celeste Posey Morley
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