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" Interleukin-10 "
[edited by] Francesco M. Marincola.
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BL
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| Record Number
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800832
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b620894
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| Main Entry
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[edited by] Francesco M. Marincola.
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| Title & Author
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Interleukin-10\ [edited by] Francesco M. Marincola.
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| Publication Statement
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Georgetown, Tex.: Eurekah.com, ©2006.
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| Series Statement
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Medical intelligence unit (Unnumbered : 2003)
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| Page. NO
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(1 volume).
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| ISBN
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1423766598
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: 1587063751
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: 1598759493
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: 9781423766599
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: 9781587063756
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: 9781598759495
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| Contents
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Structure and function of IL-10 and the IL-10 receptor / Alexander Zdanov --; IL-10 effects on innate immunity / Shin-ichiro Fujii and Michael T. Lotze --; Interleukin-10 and adaptive immune response / Simone Mocellin, Carlo Riccardo Rossi, and Pierluigi Pilati --; Experimental models for the analysis of IL-10 function / Carl G. Feng [and others] --; Role of IL-10 in autoimmune pathology / Lionel Almeras and Lionel Prin --; Interleukin-10 gene polymorphisms and cancer / W. Martin Howell --; IL-10 gene polymorphisms in transplantation / Andrey Morgun, Natalia Shulzhenko, and Maria Gerbase-DeLima --; IL-10, genetic polymorphism and its relevance to age-related diseases / Domenico Lio and Calogero Caruso --; IL-10, role in infectious diseases / Marko Kryworuchko, W. David Creery, and Ashok Kumar --; Interleukin-10 in allergic disease / Peter J. Barnes --; The role of IL-10 in autoimmune pathology / Andrew W. Gibson [and others] --; Role of interleukin-10 in transplantation / Thomas Ritter and Hans-Dieter Volk --; Role of IL-10 in reactive arthritis and ankylosing spondylitis / Joachim Sieper and Martin Rudwaleit --; Interleukin-10 and psoriasis / Khusru Asadullah, Wolfram Sterry, and Hans-Dieter Volk --; IL-10, the role in Crohn's disease / James Lindsay --; IL-10 and systemic lupus erythematosus / Simone Mocellin --; Role of IL-10 in cancer / Monica C. Panelli and Francesco M. Marincola.
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| Abstract
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Interleukin-10 (IL-10) is regarded as an immune suppressant cytokine. This reputation is due to the experimental observation that IL-10 decreases the function of antigen presenting cells and T helper 1 type immune responses. Surprisingly, however, IL-10 has potent anti-cancer effects since most experimental models demonstrate immune-mediated anti-tumor effects whether IL-10 is locally (tumor transfectant models) or systemically (transgenic models, administration of soluble cytokine) provided. In addition, recent work has suggested that polymorphisms of the promoter region of IL-10 may segregat.
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Interleukin-10 -- immunology.
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Interleukin-10.
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MEDICAL -- Immunology.
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| LC Classification
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QR185.8.I56E358 2006
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| Added Entry
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Francesco M Marincola
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