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" Expanding the genetic code for synthesis of proteins with native biological modifications and novel chemical, biophysical probes "
Yan-Jiun Lee
Liu, Wenshe R.
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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803857
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| Doc. No
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TL48663
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| Call number
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1771301552; 10026470
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| Main Entry
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Ouji, Leila Anna
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| Title & Author
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Expanding the genetic code for synthesis of proteins with native biological modifications and novel chemical, biophysical probes\ Yan-Jiun LeeLiu, Wenshe R.
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| College
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Texas A&M University
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| Date
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2015
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| Degree
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Ph.D.
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| field of study
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Chemistry
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2015
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| Page No
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190
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| Note
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Committee members: Begley, Tadhg P.; Pellois, Jean-Philippe; Watanabe, Coran M. H.
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Place of publication: United States, Ann Arbor; ISBN=978-1-339-52456-6
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| Abstract
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Engineering of protein with new modifications essentially expands the protein functions which provide powerful tools for investigating significant biological questions. New modifications also offer scientists the ability to handle protein activity at will. Therefore, development of facile and robust protein modification protocol is highly desirable in almost every aspect of biological research. In combination with chemistry and biology principles, the genetic code expansion technology has emerged as an effective strategy for manipulating proteins and interrogating biological systems. In this regard, the overall objective of the presented research is to expand the chemical biology toolbox based on noncanonical amino acid incorporation and bioorthogonal chemistry.
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| Subject
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Biochemistry
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| Descriptor
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Pure sciences;Bioconjugation;Bioorthogonal reaction;Genetic code expansion;Noncanonical amino acid
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| Added Entry
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Liu, Wenshe R.
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ChemistryTexas AM University
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