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" A novel application of cu-pd dual catalyst system for the cross-coupling of styryltrifluoroborates and amides "
Mohammed Shahidul Islam
Al-Masum, Mohammad
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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804186
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| Doc. No
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TL49008
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| Call number
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1839332095; 10158614
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| Main Entry
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Yazici Cörüt, Gözde
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| Title & Author
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A novel application of cu-pd dual catalyst system for the cross-coupling of styryltrifluoroborates and amides\ Mohammed Shahidul IslamAl-Masum, Mohammad
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| College
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Tennessee State University
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| Date
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2016
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| Degree
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M.S.
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| field of study
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Chemistry
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2016
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| Page No
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104
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| Note
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Committee members: Karim, Mohammad R.; Okoro, Cosmas; Wang, Xiaofei
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| Note
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Place of publication: United States, Ann Arbor; ISBN=978-1-369-13622-7
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| Abstract
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One of the most important transformations in organic synthesis is amidation reaction because of its importance as biomolecules and synthetic products. The amide bond is unique in nature. It stores amino acids to form peptides and proteins. Many nitrogen based functionality can be created into organic systems by forming new C-N bonded organic molecules. The direct amidation reaction by cross-coupling chemistry is a challenge. A Very few works have been reported for this transformation. One of the pioneering ones is reported by Buchwald group where they use palladium catalyzed coupling reaction involving aryl chlorides and acetyl amides. We are interested to see the application of potassium styryltrifluoroborates in cross-coupling with amides, which is yet to be explored. Styryltrifluoroborates and their use in enamides formation by cross-coupling with amides are largely unknown. In this work, a unique, interesting reaction procedure has been developed by using PdCl<sub>2</sub>(d<sup> t</sup>bpf)-CuI dual catalyst system for cross-coupling chemistry to form new C-N bonded enamides. It is also a mild, less time consuming and green system employing microwave irradiation. <sup>1</sup>H NMR, <sup>13</sup>C NMR, <sup>11</sup>B NMR and <sup>19</sup>F NMR spectra have been analyzed to confirm the synthesized compounds.
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| Subject
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Organic chemistry
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| Descriptor
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Pure sciences;Amidation;Cross-coupling;Dual catalyst;Microwaves
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Al-Masum, Mohammad
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ChemistryTennessee State University
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