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" Neurostructural Correlates of Body Mass Index and Waist Circumference in Adolescents with Bipolar Disorder "
Alvi H. Islam
Goldstein, Benjamin I.
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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804347
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| Doc. No
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TL49175
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| Call number
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1861701999; 10194149
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| Main Entry
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Zhang, Wenjuan
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| Title & Author
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Neurostructural Correlates of Body Mass Index and Waist Circumference in Adolescents with Bipolar Disorder\ Alvi H. IslamGoldstein, Benjamin I.
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| College
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University of Toronto (Canada)
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| Date
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2016
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| Degree
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M.Sc.
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| field of study
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Pharmacology
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| student score
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2016
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| Page No
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91
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| Note
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Committee members: Goldstein, Benjamin I.; Lanctot, Krista; Salahpour, Ali; Taylor, Valerie
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| Note
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Place of publication: United States, Ann Arbor; ISBN=978-1-369-41613-8
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| Abstract
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Obesity among youth with bipolar disorder (BD) is associated with greater illness severity. In adult BD, obesity is associated with neurostructural differences. We examined this topic for the first time in youth. T1-weighted images of 40 BD and 48 psychiatrically healthy controls (HC) were processed using FreeSurfer to derive cortical region of interest (ROI) volumes/cortical thickness for frontal lobe (FL), prefrontal cortex (PFC), and orbitofrontal cortex (OFC), as well as subcortical ROI volumes for amygdala and hippocampus. Our results show that there was a significant BMI-by-group interaction effect on FL and OFC volumes. In the BD group only, BMI was significantly negatively associated with OFC volume, as well as FL, OFC, and PFC cortical thickness. Our results suggest that elevated BMI is associated with neurostructural changes in youth with BD but not in HC. Treatment studies examining the effect of optimizing weight on brain structure in BD are warranted.
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| Subject
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Neurosciences; Pharmacology; Medical imaging
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| Descriptor
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Biological sciences;Health and environmental sciences;BMI;Bipolar disorder;Body mass index;Brain structure;Obesity
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| Added Entry
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Goldstein, Benjamin I.
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| Added Entry
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PharmacologyUniversity of Toronto (Canada)
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