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" Synthesis, Characterization, Mechanism and Biological Evaluations of 1,2,4 - Triazole - Containing Schiff Bases, Hemiaminals and Their Metal Complexes "
Md Shafiqul Islam
Karim, Mohammad R.
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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804866
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| Doc. No
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TL49702
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| Call number
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1986473147; 10602360
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| Main Entry
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Byrd, Dustin J.
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| Title & Author
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Synthesis, Characterization, Mechanism and Biological Evaluations of 1,2,4 - Triazole - Containing Schiff Bases, Hemiaminals and Their Metal Complexes\ Md Shafiqul IslamKarim, Mohammad R.
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| College
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Tennessee State University
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| Date
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2017
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| Degree
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M.S.
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| field of study
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Chemistry
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| student score
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2017
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| Page No
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159
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| Note
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Committee members: Boadi, William Y.; Myles, Elbert L.; Siddiquee, Tasneem A.
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| Note
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Place of publication: United States, Ann Arbor; ISBN=978-0-355-34173-7
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| Abstract
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Here, we describe the syntheses of four Schiff Bases, four Hemiaminals and three metal (Cu(II), Ni(II) and Co(II)) complexes from phenanthroline dialdehyde and di-pyridylaldehydes with 4-amino-3,5-dimethyl-1,2,4-triazole. Various spectroscopic methods have been used to determine the structures. The effect of solvents and reactant concentrations on these hemiaminals formation have been studied. Stability of these hemiaminals have also been studied both in solution in DMSO and in solid form. Hemiaminal 10 synthesized from phenanthroline dialdehyde 1 was more stable in DMSO than hemiaminals 11, 12 and 13 synthesized from di-pyridylaldehydes (2, 3 and 4). But in solid form, these hemiaminals are similarly stable. The results indicated that hydrogen bonding plays a key role on the formation and stabilization of these hemiaminals.
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| Subject
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Organic chemistry
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| Descriptor
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Pure sciences;4-triazole;Apoptosis;Glutathione;Hemiaminals;Metal complexes;Schiff bases
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| Added Entry
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Karim, Mohammad R.
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ChemistryTennessee State University
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