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" Studies of some fused-ring heterocycles and 2,6-Diarylpyridine derivatives "
Sadiq, Samina
Parrick, J.
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Latin Dissertation
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| Record Number
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828206
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TLets310079
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| Main Entry
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Sadiq, Samina
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| Title & Author
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Studies of some fused-ring heterocycles and 2,6-Diarylpyridine derivatives\ Sadiq, SaminaParrick, J.
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| College
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Brunel University
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| Date
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1999
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| student score
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1999
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| Degree
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Thesis (Ph.D.)
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| Abstract
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This work reported is divided into two parts: the first part deals with quinoxaline derivatives and includes the preparation and characterisation of novel linear tricyclic quinones 1,4-diazanthracen-9,10-diones, (54) and (55). The reaction of diazanaphthoquinones and 1-acetyl-1,3-butadiene are used to produce these quinones through the Diels-Alder reaction. In addition hexaazapentacyclic 5,6,7,12,13, 14-hexaazapentacene was prepared by the reaction ofbis(2-chloroquinoxalin-3-yl)sulfide with thioxamide and the reaction of the sulfide with amines was investigated. Two different approaches to 6,13-dibutyl-5,6,7,12,13,14-hexaazapentacene are given. Derivatives of the pentacyclic, 6-thia- 5,7,12,13,14-pentaazapentacene and the unsubstituted 6,13 -dihydro compound are described. The novel N-(2,5-dimethoxy-6-nitrophenyl)guanidine is used to obtain 3-amino-5,6-dimethoxy-1 ,2,4-benzotriazine-1-oxide and 4,7 -dimethoxy-1 ,2,3 -benzotriazole is shown to be second product. Second part of the work is concerned with the development of a preparative route to 2,6-diphenylpyridines substituted with different groups on the phenyl nuclei. Several approaches were attempted. Finally, success was achieved and a series of compounds having basic chains of different length on the phenyl groups was prepared. One chain in each case had a terminal primary amine. The binding constants of the primary amines and their N-acetyl derivatives with DNA were determined using fluorescence spectroscopy.
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Quinoxaline; Anti-cancer agents
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Parrick, J.
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Brunel University
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