Identification and characterisation of novel cancer testis antigens in human cancer cells

مرکز و کتابخانه مطالعات اسلامی به زبان های اروپایی

منو

" Identification and characterisation of novel cancer testis antigens in human cancer cells "
Alsiwiehri, Naif O. Mcfarlane, Ramsay

Document Type	:	Latin Dissertation
Record Number	:	832749
Doc. No	:	TLets731727
Main Entry	:	Alsiwiehri, Naif O.
Title & Author	:	Identification and characterisation of novel cancer testis antigens in human cancer cells\ Alsiwiehri, Naif O.Mcfarlane, Ramsay
College	:	Prifysgol Bangor University
Date	:	2017
student score	:	2017
Degree	:	Thesis (Ph.D.)
Abstract	:	Carcinogenesis is a multi-step process which involves genomic instability and abnormal cellular growth over long period of time which eventually develop tumour. Cancer testis antigens consistently reported in many types of cancer which suggest its oncogenic role. But, it’s functional role in cancer still unknown and need further investigation. Also, cancer testis antigens might be used as potential targets for cancer immunotherapy due to their main presence in normal testis cells and abnormally exist in several types of human cancer. Their aberrant expression in cancer makes them useful to target human malignancies by immunotherapy. TEX19 one of the novel CT gene was identified in this study. TEX19 show interesting expression pattern due to its confined in normal testis and expressed in many cancer tissues. This expression may indicate the oncogenic activity of TEX19 gene in somatic tissue. Thus, the possible approach to use this gene as target for cancer immunotherapy and cancer prognosis and diagnosis. In addition, TEX19 might play a role in stemness state, this was observed in TEX19 depleted cells, the stem cell markers genes such as OCT
Added Entry	:	Mcfarlane, Ramsay
Added Entry	:	Bangor University