| Document Type
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BL
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| Record Number
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841824
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| Title & Author
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Handbook of mitochondrial dysfunction /\ edited by Shamim I. Ahmad.
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| Publication Statement
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Boca Raton, FL :: CRC Press,, [2019]
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| Page. NO
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1 online resource
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| ISBN
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0429443331
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: 0429811756
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: 0429811764
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: 0429811772
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: 9780429443336
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: 9780429811753
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: 9780429811760
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: 9780429811777
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1138336084
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9781138336087
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| Contents
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SECTION I: Introduction: structure and function of mitochondria -- Mitochondrial structure and function -- Structure, function and evolutionary aspects of mitochondria -- Mitochondrial genome damage, dysfunction and repair -- SECTION II: Mitochondrial dysfunction and diseases -- Instability of human mitochondrial DNA, nuclear genes and diseases -- Kearns-Sayre syndrome -- Mitochondrial dysfunction and Barth Syndrome -- Mitochondrial dysfunction in the pathophysiology of Alzheimer's disease -- Mitochondrial dysfunction in multiple sclerosis -- Mitochondrial dysfunction in chronic kidney disease -- Mitochondrial dysfunction in breast cancer: a potential target from the bench to clinical therapeutics -- Mitochondrial dysfunction and DNA methylation in atherosclerosis -- Mitochondrial dysfunction and heart diseases -- The roles of mitochondrial dysfunction in mitophagy and apoptosis and its relevance to cancer -- Mitochondrial dysfunction linking obesity and asthma -- Mitochondrial dysfunction and hearing loss -- Superoxide dismutase, mitochondrial dysfunction, and neurodegenerative diseases -- Role of post-translational modifications of mitochondrial complex I in mitochondrial dysfunction and human brain pathologies -- Heme oxygenase-1 in kidney health and disease: perspective of mitochondrial homeostasis -- Mitochondrial transplantation in myocardial ischemia and reperfusion injury -- Mitochondrial dysfunction in diabetes -- Clinical manifestation of mitochondrial disorders in childhood -- Mitochondrial dysfunction and epilepsies -- Mitochondrial dysfunction and allergic disease
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SECTION III: Factors affecting mitochondrial function -- Role of carnosic acid in protection of brain mitochondria -- Mitochondrial dysfunction and its impact on oxidative capacity of muscle -- The effects of resveratrol on the brain mitochondria -- Pathophysiology and biomarkers of mitochondrial dysfunction induced by heavy exercise -- Mitochondrial pathologies and their neuro muscular manifestations -- Mitochondrial stress and cellular senescence -- Role of mitochondrial dysfunction in human obesity -- Roles of melatonin in maintaining mitochondrial welfare: focus on renal cells -- Mitochondrial dysfunction affecting the peripheral nervous system in diabetic neuropathy and avenues for therapy -- Mitochondrial dysfunction and oxidative stress in the pathogenesis of metabolic syndrome -- SECTION IV: Immunity and toxicity -- Regulation of antiviral immunity by mitochondrial dynamics -- Mitochondrial dysfunction, immune systems, their diseases, and possible treatments -- Organophosphorus compound-induced mitochondrial disruption -- Itochondrial dysfunction in Friedreich Ataxia -- Index.
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| Abstract
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Mitochondria produce the chemical energy necessary for eukaryotic cell functions; hence mitochondria are an essential component of health, playing roles in both disease and aging. More than 80 human diseases and syndromes are associated with mitochondrial dysfunction; this book focuses upon diseases linked to these ubiquitous organelles. Accumulation of mitochondrial DNA damage results in mitochondrial dysfunction through two main pathways. Mutation in mitochondrial DNA causes diseases such as Kearns-Sayre syndrome and Pearson syndrome. Mutation in chromosomal DNA causes diseases such as Parkinson's disease and schizophrenia. These and many other diseases are reviewed in this book. Key Features Presents the detailed structure of mitochondria, mitochondrial function, roles of oxidants and antioxidants in mitochondrial dysfunction. Includes summary of both causes and effects of these diseases. Discusses current and potential future therapies for mitochondrial dysfunction diseases Explores a wide variety of diseases caused by dysfunctional mitochondria.
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| Subject
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Mitochondrial pathology, Handbooks, manuals, etc.
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| Subject
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Mitochondria-- pathology.
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| Subject
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HEALTH FITNESS-- Diseases-- General.
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MEDICAL-- Clinical Medicine.
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MEDICAL-- Diseases.
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MEDICAL-- Evidence-Based Medicine.
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MEDICAL-- Internal Medicine.
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MEDICAL-- Pharmacology.
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| Subject
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Mitochondrial pathology.
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| Subject
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SCIENCE-- Life Sciences-- Biology-- Molecular Biology.
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| Subject
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SCIENCE-- Life Sciences-- Cytology.
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| Dewey Classification
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616.042
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| LC Classification
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RB147.5.H35 2019
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| NLM classification
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QU 360
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| Added Entry
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Ahmad, Shamim I.
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