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BL
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| Record Number
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842171
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| Title & Author
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In-vitro and in-vivo tools in drug delivery research for optimum clinical outcomes /\ edited by Ambikanandan Misra, Aliasgar Shahiwala.
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| Publication Statement
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Boca Raton, FL :: CRC Press, Taylor & Francis Group,, [2018]
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, ©2018
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| Page. NO
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1 online resource (xvii, 332 pages) :: illustrations, portraits
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| ISBN
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1315150042
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: 1351368710
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: 1351368729
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: 9781315150048
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: 9781351368711
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: 9781351368728
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1138555606
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9781138555600
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| Bibliographies/Indexes
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Includes bibliographical references and index.
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| Contents
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Cover; Half Title; Title Page; Copyright Page; Table of Contents; Preface; List of Abbreviations; Editors; Contributors; Chapter 1: In-Vitro and In-Vivo Tools in Emerging Drug Delivery Scenario: Challenges and Updates; 1.1 Introduction; 1.2 In-Vitro and In-Vivo Assessment: Why Is It Needed Particularly for NDDS?; 1.2.1 Challenges-In-Vitro Studies; 1.2.1.1 Particle Size, Zeta Potential and Stability; 1.2.1.2 Dissolution/Release Studies; 1.2.2 Challenges-In-Vivo Studies; 1.3 In-Vitro Characterization of NDDS; 1.3.1 Product Quality Attributes; 1.3.1.1 Complexes; 1.3.1.2 Conjugates.
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1.3.1.3 Encapsulated Systems1.3.1.4 Lipid-Based Systems; 1.3.2 Product Performance Attributes; 1.3.2.1 In-Vitro Drug Release Studies; 1.3.2.2 Hemolytic Assay; 1.3.2.3 Electrolyte Stability Study; 1.3.2.4 Cell Culture Studies; 1.3.2.5 Cellular Uptake and Cell Binding Studies; 1.3.2.6 In-Vitro Cytotoxicity Studies; 1.3.2.7 Oxidative Stress; 1.3.2.8 Apoptosis and Mitochondrial Dysfunction; 1.4 In-Vivo Performance Evaluation of NDDS; 1.5 Regulatory Guidance; 1.6 Conclusions; References; Chapter 2: Intraoral and Peroral Drug Delivery Systems; 2.1 Introduction.
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2.2 Evaluation of Intraoral Drug Delivery Systems2.2.1 Evaluation of Taste Masking; 2.2.2 In-Vitro Mucoadhesion Tests; 2.2.3 In-Vitro Dissolution Testing of Intraoral Dosage Forms; 2.2.3.1 Dissolution of Sublingual Tablets; 2.2.3.2 Dissolution of Chewing Gum; 2.2.3.3 Dissolution of Buccal Patches; 2.2.3.4 Dissolution of Buccal Films; 2.2.3.5 Dissolution of Lozenges; 2.2.3.6 Dissolution of Buccal Mucoadhesive Tablets; 2.2.4 In-Vitro Drug Permeation Studies; 2.2.5 In-Vivo Methods; 2.2.5.1 Residence Time; 2.2.5.2 Buccal Absorption Test; 2.3 Models for Assessing Intestinal Permeability.
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2.3.1 In-Vitro Methods 2.3.1.1 Flow-Through Diffusion Cells; 2.3.2 In Situ Models; 2.3.2.1 Intestinal Perfusion; Circular Perfusion Method; Single-Pass Perfusion; 2.3.2.2 Intestinal Loop Method; 2.3.2.3 Intestinal Vascular Cannulation; 2.3.3 In-Vivo Methods; 2.3.3.1 Use of X-Ray; 2.3.3.2 Use of Gamma Scintigraphy; 2.3.3.3 Use of Pharmacoscintigraphy; 2.3.3.4 In-Vivo Imaging Systems; 2.4 In-Vitro-In-Vivo Correlations; References; Chapter 3: Transdermal Drug Delivery Systems; 3.1 Introduction; 3.1.1 Skin Structure: Anatomy, Physiology and Barrier Functions.
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3.1.2 Principles and Different Routes of Penetration Across the Skin 3.1.2.1 Transepidermal Route; 3.1.2.2 Transfollicular Routes; 3.2 Factors Affecting Permeation Across the Skin; 3.2.1 Physiochemical Factors of Permeant; 3.2.2 Formulation Factors; 3.2.3 Physiological Factors; 3.3 Methods to Enhance Skin Permeability; 3.3.1 Passive Methods; 3.3.2 Active Methods; 3.3.2.1 Iontophoresis; 3.3.2.2 Electroporation; 3.3.2.3 Sonophoresis and Phonophoresis; 3.3.2.4 Magnetophoresis; 3.3.2.5 Thermophoresis; 3.3.2.6 Skin Abrasion; 3.4 Experimental Methods to Assess Skin Permeability.
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| Abstract
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"This book covers the essentials of drug delivery research and provides a unique forum for scientific experimental methods that are exclusively focused by the in-vitro, ex-vivo, and in-vivo methodologies of drug delivery research and felicitates translational research. The book includes recent and novel approaches in evaluation methods of transdermal, nasal, ocular, oral and intraoral, gastro-retentive, colon-targeted, and brain-targeted drug delivery systems. Providing up to date and comprehensive information, this text is invaluable to students, teachers, scientists, and others employed in the field of drug delivery."--Provided by publisher.
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| Subject
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Drug delivery systems-- Research-- Methodology.
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| Subject
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Drug development.
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Drug Delivery Systems-- methods.
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Drug targeting.
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MEDICAL-- Pharmacology.
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| Subject
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Pharmaceutical technology.
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| Dewey Classification
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[E]
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615.1/9
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WB035
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WB042
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WB043
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WB057
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WB061
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WB062
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WB075
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[E]
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| LC Classification
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RM301.25.I58 2018
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| NLM classification
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QV 785
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| Added Entry
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Misra, Ambikanandan
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Shahiwala, Aliasgar
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