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BL
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| Record Number
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844781
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| Main Entry
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Hallenbeck, William H.
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| Title & Author
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Quantitative risk assessment for environmental and occupational health /\ W.H. Hallenbeck and K.M. Cunningham.
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| Publication Statement
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Boca Raton, FL :: CRC Press,, 2018, ©1986.
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| Series Statement
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CRC revivals
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| Page. NO
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1 online resource
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| ISBN
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1351076167
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: 1351084615
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: 9781351076166
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: 9781351084611
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1315897067
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9781315897066
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| Bibliographies/Indexes
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Includes bibliographical references and index.
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| Contents
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Cover; Half Title; Title Page; Copyright Page; Dedication; Preface; Acknowledgments; Table of Contents; 1.0 Introduction; 1.1 Contents; 1.2 Methods; 1.3 Limitations; 2.0 Exposure Characterization; 2.1 Exposure scenario; 2.2 Material characteristics; 2.3 Risk group characteristics; 2.4 Summary; 3.0 Qualitative Evaluation of Human and Animal Studies; 3.1 Control data; 3.2 Latent period, effective exposure, and followup; 3.3 Matching of experimental and risk groups; 3.4 Animal studies: special considerations; 3.5 Epidemiology studies: special considerations
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3.6 Classification of toxicants by health effect and dose-response character3.6.1 Carcinogens; 3.6.2 Germ-cell mutagens; 3.6.3 Developmental toxicants; 3.6.4 Organ/tissue toxicants; 3.6.5 Summary; 3.7 Data Bases; 3.7.1 Threshold limit values (TLVs) and permissible exposure limits (PELs); 3.7.2 Human data; 3.7.3 Animal data; 3.7.4 Units of dose rate; 3.7.5 Hierarchy of data selection; 3.8 Summary; 4.0 Quantitative Evaluation of Human and Animal Studies; 4.1 Calculation of human dose from animal and human studies; 4.2 Quantitation of response; 4.3 Tests of significance
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4.4 Calculation of control-adjusted test group response4.5 Calculation of the upper limit of control-adjusted test group response; 5.0 Risk Analysis; 5.1 Individual excess risk; 5.1.1 Experimental dose range; 5.1.2 Subexperimental dose range; 5.1.3 Risk factor analysis; 5.1.4 Plausibility analysis; 5.2 Excess cases; 5.2.1 Experimental dose range; 5.2.2 Sub experimental dose range; 5.3 Sensitivity analysis; 6.0 Acceptable Concentrations; 6.1 Risk analysis method for toxicants with zero thresholds (e.g. carcinogens); 6.1.1 Acceptable individual excess risk
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6.1.2 Acceptable number of excess cases6.2 Safety factor method for toxic ants with nonzero thresholds; 7.0 Example: Environmental and Occupational Exposure to a Hypothetical Industrial Toxicant; 7.1 Solutions based on a rat study; 7.1.1 Lowest effective human dose; 7.1.2 Test and control group response; 7.1.3 Statistical significance of the difference between test and control group responses; 7.1.4 Control-adjusted test group response; 7.1.5 Upper limit of the control-adjusted test group response; 7.1.6 Maximum dose to an individual in the general population
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7.1.7 Maximum individual excess risk for the general population and workers7.1.8 Risk factors; 7.1.9 Maximum individual excess risk for the general population and workers; 7.1.10 Excess cases and excess cases per year for the general population; 7.1.11 Excess cases and excess cases per year for workers; 7.1.12 Acceptable concentrations for the general population; 7.1.13 Acceptable concentrations for workers; 7.2 Solutions based on an occupational epidemiology study; 7.2.1 Lowest effective human dose; 7.2.2 Test and control group response
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| Abstract
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Many individuals and groups need a usable treatment of the methodology required to assess the human health risks caused by toxicant exposure. This need is shared by industrial hygienists, environmental, occupational and public health professionals, toxicologists, epidemiologists, labor unions, attorneys, regulatory officials, and manufacturers and users of chemicals. The reader needs only a basic knowledge of biology adn algebra in order to utilize the methodology presented. In addition, a basic knowledge of toxicology, epidemiology, and statistics is derisrable for a full understanding of some aspects of risk assessment. Sophisticated computer programs are not required. All the computations can be carried out with a pocked calculator.
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| Subject
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Environmental health-- Statistical methods.
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Health risk assessment-- Statistical methods.
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Industrial hygiene-- Statistical methods.
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BUSINESS ECONOMICS-- Infrastructure.
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Environmental health-- Statistical methods.
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Health risk assessment-- Statistical methods.
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Industrial hygiene-- Statistical methods.
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SOCIAL SCIENCE-- General.
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| Dewey Classification
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363.1
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| LC Classification
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RA427.3
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| Added Entry
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Cunningham, K. M., (Kathleen M.)
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