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BL
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| Record Number
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844928
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| Main Entry
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Bourne, DavidW. A.
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| Title & Author
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Mathematical Modeling of Pharmacokinetic Data.
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| Publication Statement
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Boca Raton :: Routledge,, 2018.
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| Page. NO
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1 online resource (153 pages)
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| ISBN
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1351433253
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: 9781351433259
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| Contents
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Cover; Half Title; Title Page; Copyright Page; Dedication; Table of Contents; Preface; Chapter 1: Why Model the Data?; 1.1 Condense the Data; 1.2 Exploring Mechanisms; 1.3 Making Predictions; Chapter 2: General Approach; 2.1 General Method; 2.2 Error in y Alone; 2.3 Parameter Adjustments; Chapter 3: Pharmacokinetic Models; 3.1 Compartmental Models; 3.2 Physiologically Based Models; 3.3 Pharmacodynamic Models; Chapter 4: Simulation of Data; 4.1 Explicit Equations; 4.2 Implicit Equations; 4.3 Differential Equations; 4.4 Integration Using Laplace Transforms.
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4.5 Numerical Integration of Differential EquationsChapter 5: Initial Estimates; 5.1 Graphical Methods; 5.2 Linear Regression; 5.3 Curve Stripping; 5.4 Area under the Curve Estimation; 5.5 Deconvolution; Chapter 6: Nonlinear Regression; 6.1 Grid Search Method; 6.2 Steepest Descent Method; 6.3 Gauss-Newton Methods; 6.4 Simplex Method; 6.5 Local Minima; Chapter 7: Weighting Schemes; 7.1 Equal Weight; 7.2 Variance Model; 7.3 Iteratively Reweighted Least Squares; 7.4 Extended Least Squares; 7.5 Bayesian Methods; 7.6 Analysis of Population Data; Chapter 8: Evaluation of Program Output.
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8.1 Tabular Output8.2 Graphical Output; 8.3 Statistical Output; Chapter 9: Experimental Design; 9.1 Pilot Study; 9.2 Identifiability-Sampling Sites; 9.3 Optimal Sampling-Sampling Times; 9.4 Model Testing; Appendix; References; Index.
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| Subject
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Pharmacokinetics-- Mathematical models.
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| Subject
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Pharmacokinetics-- Mathematical models.
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| Dewey Classification
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615/.7/0151
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| LC Classification
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RM301.5.B67 1995
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| Added Entry
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Strauss, Steven.
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