| Document Type
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BL
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| Record Number
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845836
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| Main Entry
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Chow, Shein-Chung,1955-
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| Title & Author
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Adaptive design methods in clinical trials /\ Shein-Chung Chow, Mark Chang.
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| Edition Statement
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2nd ed.
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| Publication Statement
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Boca Raton, FL :: CRC Press,, ©2012.
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| Series Statement
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Chapman & Hall/CRC biostatistics series
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| Page. NO
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1 online resource (xvi, 358 pages) :: illustrations
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| ISBN
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1439839883
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: 9781439839881
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1439839875
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9781439839874
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| Notes
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"A Chapman & Hall book."
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| Bibliographies/Indexes
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Includes bibliographical references and index.
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| Contents
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Protocol amendment -- Adaptive randomization -- Adaptive hypotheses -- Adaptive dose-escalation trials -- Adaptive group sequential design -- Statistical tests for adaptive seamless designs -- Adaptive sample size adjustment -- Two-stage adaptive design -- Adaptive treatment switching -- Bayesian approach -- Biomarker adaptive trials -- Target clinical trials -- Sample size and power estimation -- Clinical trial simulation -- Regulatory perspectives : a review of FDA draft guidance.
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| Abstract
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With new statistical and scientific issues arising in adaptive clinical trial design, including the U.S. FDA's recent draft guidance, a new edition of one of the first books on the topic is needed. Adaptive Design Methods in Clinical Trials, Second Edition reflects recent developments and regulatory positions on the use of adaptive designs in clinical trials. It unifies the vast and continuously growing literature and research activities on regulatory requirements, scientific and practical issues, and statistical methodology. New to the Second Edition Along with revisions throughout the text.
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| Subject
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Adaptive sampling (Statistics)
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| Subject
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Clinical trials-- Statistical methods.
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Clinical trials.
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Experimental design.
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Adaptive sampling (Statistics)
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Clinical trials-- Statistical methods.
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Clinical trials.
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Experimental design.
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MEDICAL-- Laboratory Medicine.
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Clinical Trials as Topic-- methods.
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Research Design.
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Biometry-- methods.
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| Subject
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Models, Statistical.
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| Dewey Classification
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610.72/4
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| LC Classification
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R853.C55C53 2012eb
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| NLM classification
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2012 A-720
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QV 20.5
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| Added Entry
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Chang, Mark.
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