| Document Type
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BL
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| Record Number
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848260
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| Main Entry
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Schwarz, Wolfgang
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| Title & Author
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Pvp : A Critical Review of the Kinetics and Toxicology of Polyvinylpyrrolidone (Povidone)
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| Publication Statement
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Boca Raton: Routledge, 2018
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| Page. NO
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1 Online-Ressource (232 Seiten)
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| ISBN
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0873712889
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: 1351420836
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: 9780873712880
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: 97813514208399780873712880
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| Abstract
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1. Absorption of PVP -- A. Rat studies -- B. Other studies -- 2. Renal Elimination of PVP -- A. Animal studies-rat -- B. Animal studies-other species -- C. Human studies-healthy subjects -- D. Human studies-patients -- 3. Distribution of PV P -- A. Pharmacokinetic studies -- B. Tissue uptake studies -- C. Histological studies -- D. Intravenous administration to humans -- E. Mechanism of uptake -- 4. Acute Toxicity of PVP -- 5. Subchronic Toxicity of PVP -- A. Rat studies -- B. Cat and dog studies -- 6. Chronic Toxicity of PVP -- A. Rat studies -- B. Dog studies -- 7. Teratogenicity of PV P -- 8. Mutagenicity of PV P -- A. In vitro studies -- B. In vivo studies -- 9. Carcinogenicity of PVP -- A. Hueper studies -- B. Rat studies-oral route -- C. Rat studies-other routes -- D. Other species -- Index
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Cover -- Half Title -- Title Page -- Copyright Page -- Table of Contents -- 1: Introduction -- Pharmaceutical Use -- Foods and Beverages -- Cosmetics and Toiletries -- Photographic Products -- Dyeing Applications and Inks -- Detergents -- Suspensions, Dispersions, and Emulsions -- Production of Plastics -- Adhesives -- Paints and Coatings -- Paper Auxiliaries -- Tabletting Auxiliéiry -- Other Industrial Uses -- 2: Synthesis and Properties of PVP -- Synthesis of PVP -- Nomenclature -- Soluble polymers -- Insoluble polymers -- Classification of PVP Polymers -- Different Methods of Assessing the Molecular Weight -- Distribution of Molecular Weights Within a Given PVP Product -- Physical and Chemical Properties -- Physical -- Chemical -- Specifications -- Presence of Contaminants in Commercially Available PVP -- Monomer -- 2-Pyrrolidone -- Hydrazine -- Acetaldehyde -- 3: Movement of Large Molecules Across Membranes-General Considerations -- Introduction -- Physicochemical Factors -- Movement of PVP Across Membranes -- Glomerular transport of PVP -- 4: Absorption of PVP by Various Routes of Administration -- Introduction -- Oral Administration -- Evidence of Absorption from Toxicity Studies -- Absorption Studies Using Chemical Analysis of PVP -- Absorption Studies Using Radio-Labelled PVP -- General problems -- Studies using radio-iodine (131I and 125I) -- Studies using radio-carbon ('14C) -- Absorption Studies Using Iodine-Labelled PVP -- Absorption Studies Using 14C-Labelled PVP -- Absorption Studies of PVP in Humans -- Discussion of Studies of Oral Absorption of PVP -- Summary of Main Findings -- Conclusions -- Intramuscular and Subcutaneous Administration of PVP -- Summary of Main Findings -- Absorption of PVP by Inhalation -- 5: Excretion and Metabolism of PVP -- Introduction -- Animal Studies -- Human Studies -- Discussion
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Of Main Findings -- Metabolism of PVP -- Biliary Excretion -- Summary of Main Findings -- 6: Distribution and Storage of PVP -- Introduction -- Pharmacokinetic Studies of PVP -- Distribution Studies of PVP -- Distribution of PVP as Measured in Histopathological and Toxicity Studies -- Summary of Main Findings -- 7: Storage of PVP in Humans -- Storage of PVP in Humans Following Intravenous Administration -- Storage of PVP in Humans Following Intramuscular or Subcutaneous Administration ("Dupont-Lachapelle Disease") -- Factors to be Considered in the Use of Polymers in Injectable Preparations -- Studies of the Effects of Inhaled PVP -- Discussion Concerning the Distribution and Storage of PVP in Tissues -- Summary of Main Findings -- 8: Functional Consequences of PVP Uptake by Body Tissues, with Particular Reference to the Reticuloendothelial System (RES) and the Immune System -- Mechanism of Uptake of PVP into Body Tissues -- General considerations -- Studies on the Mechanisms of PVP Uptake -- Functional Consequences of PVP Uptake into Body Tissues -- Effect of PVP on the RES -- PVP Shock Reactions -- Immunological Effects of PVP -- Summary of Main Findings -- 9: Toxicological Studies on PVP -- Acute Toxicity -- Subchronic Toxicity -- Parenteral Studies -- Local tissue tolerance -- Chronic Toxicity Studies -- Reproductive Toxicity Studies -- Mutagenicity Studies -- In vitro tests -- In vivo tests -- Carcinogenicity Studies -- Oral studies -- Parenteral studies -- Hueper Studies on PVP -- Discussion of the Parenteral Carcinogenicity Studies -- Anticarcinogenic Activity of PVP -- Summary of Main Findings -- 10: Overall Summary and Conclusions -- Chemistry and Uses -- Biological Activity -- Absorption -- Distribution, Storage, and Excretion -- Metabolism -- Pharmacological Effects -- Toxicology and Safety -- References -- Appendix
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| Dewey Classification
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615/.7
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| LC Classification
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RM666.P822P96 1990
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| Added Entry
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Borzelleca, J. F.
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Schwartz, S. L.
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Sullivan, F. M.
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