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BL
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| Record Number
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851729
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| Title & Author
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Pre-clinical models : : techniques and protocols /\ edited by Paul C. Guest.
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| Publication Statement
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New York, NY :: Humana Press :: Springer,, [2018]
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, ©2019
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| Series Statement
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Methods in molecular biology,; volume 1916
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| Page. NO
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1 online resource (xiii, 343 pages) :: illustrations (some color)
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| ISBN
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1493989944
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: 9781493989942
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1493989936
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9781493989935
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| Bibliographies/Indexes
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Includes bibliographical references and index.
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| Contents
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Intro; Preface; Contents; Contributors; Part I: Reviews; Chapter 1: A Guide to Mass Spectrometry-Based Quantitative Proteomics; Abbreviations; 1 Introduction; 2 Sample Preparation Methods; 2.1 SIL Techniques In Vitro; 2.1.1 Quantitation at the MS Level; 2.1.2 ICAT; 2.1.3 ICPL; 2.1.4 GIST; 2.1.5 mTRAQ; 2.2 Isobaric Tagging and Quantitation at the MS/MS Level; 2.2.1 iTRAQ; 2.2.2 TMT; 2.2.3 TMT Isobaric Isotopologues; 2.3 SIL Techniques In Vivo; 2.3.1 SILAC; 2.3.2 pSILAC; 2.3.3 Super-SILAC; 2.3.4 SILAM; 2.4 LFQ; 2.4.1 AQUA; 2.4.2 QconCAT; 2.4.3 LRP; 2.4.4 PSAQ; 2.4.5 Other Methods
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3 Methods of Data Acquisition3.1 Targeted Quantitation; 3.1.1 SRM and MRM; 3.1.2 PRM; 3.2 DDA; 3.2.1 Spectral Counting; 3.2.2 Spectral Counting Normalization; 3.2.3 Ion Abundance/Ion Counting; 3.2.4 Ion Abundance Normalization; 3.2.5 Additional Resources; 3.3 DIA; 3.3.1 CE Alternation; 3.3.2 Fragmentation Windows; 3.3.3 DIA Software; 4 Additional Tools; 4.1 SPS-MS3; 4.2 Proteomic Ruler; 4.3 AP-MS; 5 Method Comparisons; 5.1 Absolute or Relative Quantitation; 5.1.1 Absolute Quantitation; 5.1.2 Relative Quantitation; 5.2 SIL or LFQ; 5.2.1 SIL; 5.2.2 LFQ; 5.3 Targeted, DDA or DIA; 5.3.1 Targeted
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3.2 Carrying out the Test3.3 Data Analysis; 4 Notes; References; Chapter 5: The Forced Swim Test for Depression-Like Behavior in Rodents; 1 Introduction; 2 Materials; 3 Methods; 3.1 Experimental; 3.2 Data Analysis; 4 Notes; References; Chapter 6: Object Burying Test for Assessment of Obsessive Compulsive Behaviors in Mice; 1 Introduction; 2 Materials; 3 Methods; 4 Notes; References; Chapter 7: The Nest Building Test in Mice for Assessment of General Well-Being; 1 Introduction; 2 Materials; 3 Methods; 4 Notes; References; Chapter 8: Free Dyadic Social Interaction Test in Mice; 1 Introduction
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5.3.2 DDA5.3.3 DIA; 6 Concluding Remarks; References; Chapter 2: Mitochondrial Involvement in Mental Disorders; Energy Metabolism, Genetic, and Environmental Factors; 1 Introduction; 2 Mitochondria; 3 Mitochondrial Abnormalities in Mental Disorders; 4 Mitochondria-Related Genes in Mental Disorders; 5 Environmental Factors for Mental Disorders; 6 Interactions of Environmental Factors and Mitochondria-Related Genes; 7 Conclusions; References; Chapter 3: Monosodium Glutamate (MSG)-Induced Animal Model of Type 2 Diabetes; 1 Introduction; 2 MSG and Glucose and Insulin Homeostasis
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| Subject
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Medicine-- Simulation methods.
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| Subject
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Mice.
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| Subject
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Models, Animal.
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| Dewey Classification
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610.72
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| LC Classification
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R859.7.C65
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| Added Entry
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Guest, Paul C.
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