| Document Type
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BL
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| Record Number
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852919
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| Title & Author
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New research on cell aging and death /\ Roman Strakos̆, Bendt Lorens, editors.
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| Publication Statement
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New York :: Nova Biomedical,, [2018]
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, ©2018
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| Series Statement
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Cell biology research progress
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| Page. NO
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1 online resource.
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| ISBN
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1536136271
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: 9781536136272
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1536136263
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9781536136265
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| Bibliographies/Indexes
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Includes bibliographical references and index.
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| Contents
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Intro; Contents; Preface; Chapter 1; The SAMP8 Mouse as a Model of Accelerated Senescence; Abstract; 1. Introduction; 2. Background on the SAM Strains; 3. SAMP8 as a Neurodegeneration Model; 3.1. Life Expectancy; 3.2. Learning and Memory Deficits; 3.2.1. Spatial Learning and Memory Ability; 3.2.2. Avoidance Response Capability; 3.2.3. Object Recognition; 3.2.4. Fear Conditioning; 3.3. Altered Emotional Behavior; 3.4. Age-Related Changes in Circadian Rhythm; 3.5. Neuropathological Features; 3.5.1. Oxidative Stress; 3.5.2. Neuromorphological Alterations; 3.5.3. Gliosis
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Biographical SketchChapter 4; Neocortical Adult Neurogenesis during Aging; Abstract; Introduction; Adult Neurogenesis in the SVZ and Aging; Adult Neurogenesis in the HDG and Aging; Neocortical Adult Neurogenesis and Aging; Conclusion; References; Short Communication; Nicotinamide Adenine Dinucleotide (NAD+) and Cell Aging; Abstract; Abbreviations; Introduction; Metabolism of NAD+; NAD+-Dependent Biological Reactions; TCA Cycle, ETC, and Mitochondrial Functions; Poly(ADP-ribosyl)ation (PARylation); Sirtuin Proteins; NAD+ and Aging/Cancer; NAD+ and Aging; NAD+ and Cancer
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NAD+ and Neurodegenerative DiseasesTranscriptional Regulation of Mitochondrial Function- and DNA Repair-Associated Genes; Materials and Methods; Materials; Cells and Cell Culture; NAD+/NADH Assay; Construction of Luciferase Expression Reporter Plasmids; DNA Transfection and Luc Assay; Results; Upregulation of NAD+/NADH Ratio by Chemical Compounds, Including Rsv; Analysis of Promoter Activities of the Human DNA Repair-Associated Genes; Discussion; Conclusion; Acknowledgments; References; Biographical Sketch; Index; Blank Page
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The Effect of NETosis on Inflammatory ReactionsAutophagy as a Maintaining Process for Neutrophil Homeostasis and a Mechanism of Death That Regulates Inflammation; Conclusion; Acknowledgment; References; Chapter 3; Candidiasis and the Mechanism of Action for Anti-Candida Compounds; Abstract; Introduction; Candidiasis in Human Fungal Infections; Targeting the Cell Wall; Alteration of Cytoplasmic Membranes; Inhibition of Fungal Nucleic Acid, Protein, and Microtubule Synthesis; Targeting of Calcineurin Signaling; Reactive Oxygen Species and Programmed Cell Death; Conclusion; References
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| Subject
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Aging-- Molecular aspects.
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| Subject
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Apoptosis.
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Cells-- Aging.
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Cell Death.
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Aging-- Molecular aspects.
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Apoptosis.
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Cells-- Aging.
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| Subject
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SCIENCE-- Life Sciences-- Biology.
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| Dewey Classification
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574.87/65
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| LC Classification
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QH608
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| NLM classification
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QU 375
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| Added Entry
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Lorens, Bendt
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Strakos̆, Roman
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