|
" Long non-coding RNA : "
Antonin Morillon ; RNA set coordinated by Marie-Christine Maurel.
| Document Type
|
:
|
BL
|
| Record Number
|
:
|
856033
|
| Main Entry
|
:
|
Morillon, Antonin
|
| Title & Author
|
:
|
Long non-coding RNA : : the dark side of the genome /\ Antonin Morillon ; RNA set coordinated by Marie-Christine Maurel.
|
| Publication Statement
|
:
|
London :: ISTE Press :: Elsevier,, 2018.
|
| Page. NO
|
:
|
1 online resource :: color illustrations
|
| ISBN
|
:
|
0081023553
|
|
|
:
|
: 9780081023556
|
|
|
:
|
1785482653
|
|
|
:
|
9781785482656
|
| Bibliographies/Indexes
|
:
|
Includes bibliographical references and index.
|
| Contents
|
:
|
Foreword: The modern RNA world -- Preface -- 1. Non-coding RNA, its history and discovery timeline -- 2. Definition and families of long non-coding RNA -- 3. Biological functions of long non-coding RNA -- 4. Non-coding RNA in development -- 5. Long non-coding RNA and cancer -- Concluding perspectives -- Bibliography -- Glossary -- List of acronyms -- Index.
|
| Abstract
|
:
|
The dark side of the genome represents vast domains of the genome that are not encoding for proteins - the basic bricks of cellular structure and metabolism. Up to 98% of the human genome is non-coding and produces so-called long non-coding RNA. Some of these non-coding RNA play fundamental roles in cellular identity, cell development and cancer progression. They are now widely studied in many organisms to understand their function. This book reviews this expanding field of research and present the broad functional diversities of those molecules and their putative fundamental and therapeutic roles and develops the recent history of non-coding RNA, their very much debated classification and how they raise a formidable interest for developmental and tumorigenesis biology. Using classical examples and an extensive bibliography, the book illustrates the most studied and attractive examples of these long non-coding RNA, how they interface with epigenetics, genome integrity and expression and what are the current models of their regulatory mechanisms. This book offers a large review about the long non-coding RNAIt presents the broad functional diversities of those moleculesIt presents pioneer works from the fieldProvides a comprehensive review of the field Presents fundamental and therapeutic interests.
|
| Subject
|
:
|
Non-coding RNA.
|
| Subject
|
:
|
Non-coding RNA.
|
| Subject
|
:
|
SCIENCE-- Life Sciences-- Biochemistry.
|
| Subject
|
:
|
RNA, Long Noncoding.
|
| Dewey Classification
|
:
|
572.8/8
|
| LC Classification
|
:
|
QP623.5.N6M65 2018eb
|
| Added Entry
|
:
|
Maurel, Marie-Christine.
|
| |