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BL
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| Record Number
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856425
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| Title & Author
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Capillary electrophoresis-mass spectrometry for metabolomics /\ editor: Rawi Ramautar.
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| Publication Statement
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Cambridge :: Royal Society of Chemistry,, 2018
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| Series Statement
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New developments in mass spectrometry ;; 6
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| Page. NO
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1 online resource (286 pages)
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| ISBN
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1788012739
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: 1788014847
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: 9781788012737
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: 9781788014847
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178801104X
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9781788011044
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| Notes
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Includes index.
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Title from title details screen.
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| Bibliographies/Indexes
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Includes bibliographical references and index.
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| Contents
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Front Cover; Capillary Electrophoresis-Mass Spectrometry for Metabolomics; Preface; About the Editor; Contents; Chapter 1 -- Capillary Electrophoresis-Mass Spectrometry for Metabolomics -- From Metabolite Analysis to Metabolic Profiling; 1.1 Introduction; 1.2 Capillary Electrophoresis for Metabolite Analysis; 1.3 Capillary Electrophoresis-Mass Spectrometry for Metabolomics; 1.4 Conclusions; Acknowledgements; References; Chapter 2 -- CE-MS Workflows for Metabolomics: A Focus on Sample Preparation; 2.1 Introduction; 2.2 Sample Preparation: General Aspects; 2.3 Sample Preparation for Body Fluids
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2.3.1 Urine2.3.2 Blood, Plasma and Serum; 2.3.3 Other Biofluids; 2.4 Sample Preparation for Mammalian Cultured Cells; 2.5 Sample Preparation for Solid Samples: Tissues and Plants; 2.6 Sample Preparation for Microbial Cells, Parasites and Microbiota; 2.7 Conclusions; Acknowledgements; References; Chapter 3 -- Capillary Electrophoresis-Mass Spectrometry Using Non-covalently Coated Capillaries for Metabolic Profiling of Biological Samples; 3.1 Introduction; 3.2 Capillary Coatings in CE-MS; 3.3 Non-covalently Coated Capillaries for CE-MS-based Metabolomics
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3.4 PB-PVS and PB-DS-PB Coated Capillaries: Practical Aspects3.5 Conclusions; Acknowledgements; References; Chapter 4 -- Capillary Electrophoresis-Mass Spectrometry for Metabolomics Using New Interfacing Designs; 4.1 Introduction; 4.2 Low-flow Sheath-liquid Interfacing Designs; 4.3 Sheathless Interfacing Designs; 4.4 Conclusions; Acknowledgements; References; Chapter 5 -- Stacking or On-line Sample Concentration in CE-MS for Metabolomics; 5.1 Introduction; 5.2 Stacking Techniques -- an Overview; 5.2.1 Field Amplification or Enhancement; 5.2.2 Transient Isotachophoresis (tITP)
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5.2.3 Dynamic pH Junctions5.2.4 Sweeping; 5.2.5 Analyte Focusing by Micelle Collapse (AFMC); 5.2.6 Micelle to Solvent Stacking (MSS); 5.2.7 Hyphenated Stacking; 5.3 Considerations for Stacking in CE-MS-based Metabolomics Studies; 5.3.1 Stacking with MS-compatible Reagents; 5.3.2 Stacking with Non-volatile Reagents; 5.4 Applications of Stacking in CE-MS-based Metabolomics Studies; 5.4.1 Applications of Field Amplification/Enhancement; 5.4.2 Applications of tITP; 5.4.3 Applications of Dynamic pH Junctions; 5.4.4 Applications of Sweeping, AFMC and MSS; 5.4.5 Applications of Hyphenated Stacking
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5.5 ConclusionAcknowledgements; References; Chapter 6 -- On-line Solid-phase Extraction Capillary Electrophoresis-Mass Spectrometry and Data Analysis Approaches for Metabolomics; 6.1 Introduction; 6.2 Experimental Procedures; 6.2.1 Mouse Blood Plasma Extraction; 6.2.2 Sample Preparation; 6.2.3 Apparatus and Procedures: SPE-CE-MS; 6.2.3.1 Construction of an SPE-CE Microcartridge; 6.2.3.2 SPE-CE-MS Methodology; 6.2.4 Multivariate Data Analysis: MCR-ALS and PLS-DA; 6.3 Results and Discussion; 6.3.1 Plasma Pretreatment; 6.3.2 Analysis of Plasma Samples by C18-SPE-CE-MS
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| Abstract
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In this book, the unique features of CE-MS for metabolomics studies are highlighted and a comprehensive overview of recent technological developments is given at a level suitable for researchers working in metabolomics, bioanalytics and biomarker analysis.
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| Subject
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Capillary electrophoresis.
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Mass spectrometry.
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Biochemistry.
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Capillary electrophoresis.
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Mass spectrometry.
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| Subject
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SCIENCE-- Chemistry-- Physical Theoretical.
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| Dewey Classification
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541/.372
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| LC Classification
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QP519.9.C36
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| Added Entry
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Ramautar, Rawi
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