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BL
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| Record Number
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856427
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| Title & Author
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Stimuli-responsive drug delivery systems /\ editors: Amit Singh, Mansoor M. Amiji.
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| Publication Statement
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Cambridge :: Royal Society of Chemistry,, 2018.
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| Page. NO
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1 online resource (360 pages)
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| ISBN
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1788013530
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: 9781788013536
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9781788011136
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| Notes
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Includes index.
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Title from title details screen.
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| Contents
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Cover; Stimuli-responsive Drug Delivery Systems; Preface; Dedication; Contents; Chapter 1 -- Fundamentals of Stimuli-responsive Drug and Gene Delivery Systems; 1.1 Introduction; 1.2 pH-Sensitive DDS; 1.3 Redox Potential-sensitive DDS; 1.4 Enzyme-sensitive DDS; 1.5 Thermo-sensitive DDS; 1.6 Magnetically-sensitive DDS; 1.7 Ultrasound-sensitive DDS; 1.8 Light-sensitive DDS; 1.9 Stimuli-sensitive DDS for Combination Therapy: Case of Cancer; 1.10 Concluding Remarks; References; Chapter 2 -- Materials and Chemistry of Stimuli-responsive Drug Delivery Systems; 2.1 Introduction; 2.2 Physical Stimuli
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2.2.1 Thermoresponsive Materials2.2.2 Photoresponsive Materials; 2.2.2.1 Photoisomerizable Groups; 2.2.2.2 Photo-cleavable Groups; 2.2.3 Magnetically Responsive Materials; 2.3 Chemical Stimuli; 2.3.1 pH Responsive Materials; 2.3.2 Thiol-responsive Materials; 2.4 Biological/Biochemical Stimuli; 2.5 Summary; References; Chapter 3 -- pH-responsive Drug Delivery Systems; 3.1 Introduction; 3.1.1 pH Environment in Gastrointestinal Organs; 3.1.2 Acidic pH Environment in Pathological Tissues; 3.1.3 Acidic Subcellular Organelles; 3.2 Classification of pH-responsive Materials
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3.2.1 Polymers with Ionizable Functional Groups3.2.1.1 pH-responsive Acidic Polymers; 3.2.1.2 pH-responsive Basic Polymers; 3.2.1.3 pH-responsive Natural Polymers; 3.2.2 Acid-labile pH-sensitive Nanocarriers; 3.2.3 pH-responsive Inorganic Nanoscale Materials; 3.3 Release Mechanism of pH-responsive DDS; 3.3.1 Hydrophobic-Hydrophilic Transition Induced Disassembly; 3.3.2 Cleavage of Acid-labile Linkers for Drug Release; 3.3.3 Gel Swelling; 3.3.4 Cap/Coating Removal; 3.3.5 Gas Generation; 3.4 pH-responsive DDS for Targeted Delivery; 3.4.1 PEG Shedding; 3.4.2 Ligand Shielding/Deshielding
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3.4.3 Ligand Pop-up Targeting3.4.4 Charge Reversal; 3.4.5 Size Change; 3.4.6 Membrane Fusion by pH-sensitive Peptides; 3.4.6.1 pH-(Low) Insertion Peptide (pHLIP); 3.4.6.2 pH-activatable Cell-penetrating Peptides CPPs; 3.5 pH-responsive DDS for Intracellular Delivery; 3.6 Conclusions; References; Chapter 4 -- Thermo-responsive Nanomedicines for Drug Delivery in the Gastrointestinal Tract; 4.1 Introduction; 4.2 Gastrointestinal Tract; 4.2.1 Constitution of the Gastrointestinal Tract; 4.2.2 Differences Between Normal and Diseased Tissues; 4.2.3 Inflammatory Bowel Disease
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4.2.4 Gastric and Colorectal Cancer4.3 Thermo-responsive Materials and Nanocarrier Systems; 4.3.1 Thermo-responsive Polymeric Nanoparticles; 4.3.2 Thermo-responsive Liposomes; 4.3.3 Thermo-responsive Micelles; 4.4 Conclusions and Future Perspectives; Acknowledgements; References; Chapter 5 -- Redox-responsive Drug Delivery Systems; 5.1 Redox-responsive Drug Delivery Systems; 5.1.1 Redox Profile of the Tumor Microenvironment and the Cancer Cell; 5.1.1.1 Reactive Oxygen Species; 5.1.1.2 Glutathione; 5.1.1.3 Redox Potential in Cancer Cell; 5.1.2 Reduction (Glutathione)-responsive Systems
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| Abstract
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This book provides a comprehensive account on the design, materials chemistry, and application aspects behind these novel stimuli-responsive materials.
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| Subject
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Drug delivery systems.
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Drug delivery systems.
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MEDICAL-- Pharmacology.
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Pharmaceutical technology.
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Drug Delivery Systems.
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Biocompatible Materials-- pharmacology.
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| Dewey Classification
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615/.6
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| LC Classification
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RS199.5
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| NLM classification
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2018 I-765
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QV 785
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| Added Entry
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Amiji, Mansoor M.
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Singh, Amit
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