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" Prefoldins : "
Nabil Djouder, editor.
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BL
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| Record Number
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859271
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| Title & Author
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Prefoldins : : the new chaperones /\ Nabil Djouder, editor.
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| Publication Statement
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Cham :: Springer,, [2018]
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| Series Statement
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Advances in experimental medicine and biology
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| Page. NO
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1 online resource
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| ISBN
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3030007375
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: 9783030007379
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3030007367
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9783030007362
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| Notes
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Includes index.
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| Bibliographies/Indexes
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Includes bibliographical references and index.
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| Contents
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Preface -- Structure of the molecular chaperone prefoldin -- Structure and function of archaeal prefoldin -- Role and functions of prefoldins -- Nuclear functions of prefoldins -- The yeast prefoldin Bud27 -- URI-like prefoldin complex -- HSP90 and its R2TP/Prefoldin-like cochaperone -- Role and functions of URI: mouse models for URI -- Nuclear function of URI-like prefoldin complex -- URI and androgen regulation. Index.
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| Abstract
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This book reviews recent work on molecular chaperones of the prefoldin family from their discovery in Archaea to the basic clarification of their structure. Even though, there is still a lot to investigate in order to understand the roles and functions of prefoldins, some preliminary work suggests their contribution in assembly and activation of a variety of macromolecular complexes. Hence, the reader is introduced to recent structural findings via cryo-electron microscopy and to the importance of this particular group of proteins in health and disease. This book also discusses the particular structure of the URI prefoldin-like complex. In addition, recent developments in the generation of URI mouse models speculate on the functions and emerging roles of the URI prefoldin-like complex in various cellular processes. This novel protein complex represents a unique cellular machinery, which molecular basis of its activity still remains to be determined. This work is thus a guide to help researchers in the field to have a more comprehensive and critical view of the prefoldin world.
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| Subject
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Molecular chaperones.
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Molecular chaperones.
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Molecular Chaperones.
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Intracellular Signaling Peptides and Proteins.
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| Subject
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Protein Conformation.
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| Dewey Classification
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572/.6
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| LC Classification
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QP552.M64P74 2018
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| NLM classification
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QU 55.6
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| Added Entry
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Djouder, Nabil.
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