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BL
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| Record Number
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859680
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| Main Entry
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Yao, Li,1968-
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| Title & Author
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Glial cell engineering in neural regeneration /\ Li Yao.
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| Publication Statement
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Cham, Switzerland :: Springer,, ]2018]
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| Page. NO
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1 online resource
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| ISBN
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3030021041
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: 303002105X
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: 3030132072
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: 9783030021047
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: 9783030021054
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: 9783030132071
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3030021033
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9783030021030
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| Bibliographies/Indexes
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Includes bibliographical references and index.
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| Contents
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Intro; Preface; Contents; Chapter 1: Advances in the Research of Astrocyte Function in Neural Regeneration; 1.1 Astrocytes in the Central Nervous System; 1.2 Types of Astrocytes; 1.3 Functions of Astrocytes in CNS; 1.3.1 Control of Extracellular Homeostasis; 1.3.2 Removal of Excess Glutamate; 1.3.3 Maintenance of Glutamatergic Neurotransmission; 1.3.4 Control of Local Blood Flow and Metabolic Support for Neurons; 1.3.5 Control of Synaptogenesis and Its Maintenance; 1.3.6 Tripartite Synapse; 1.3.7 Signaling in Glial Syncytia; 1.3.8 Concept of Gliotransmission
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1.4 Role of Astrocytes in Neurodegenerative Diseases1.5 Role of Astrocytes in Neural Injury; 1.6 Importance of Astrocytes in Neural Regeneration; 1.7 Astrocyte Transplantation in Neural Regeneration; References; Chapter 2: Enhancement of Axonal Myelination in Wounded Spinal Cord Using Oligodendrocyte Precursor Cell Transplantation; 2.1 Axonal Myelination in Central Nervous System; 2.2 Axon Demyelination Resulting from Spinal Cord Injury; 2.3 Restoration of Axonal Myelination Post-Spinal Cord Injury; 2.4 Transplantation of OPCs Enhancing Axon Remyelination in Spinal Cord Injury
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2.4.1 Transplantation of OPCs in Therapy of SCI2.4.2 Co-Transplantation of Biomaterial Scaffolds and OPCs for SCI Therapy; 2.5 Potential Application of Electrical Stimulation in Axonal Myelination; References; Chapter 3: Application of Schwann Cells in Neural Tissue Engineering; 3.1 Origin of Schwann Cells; 3.2 Peripheral Nerve Injury and Role of Schwann Cells in Nerve Regeneration; 3.3 Autologous Nerve Grafting and Schwann Cell Transplantation for Nerve Repair; 3.4 Synthetic and Biological Molecules for Promoting Nerve Repair; 3.5 Stem Cell-Derived Schwann Cells for Neural Regeneration
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3.6 Schwann Cells and Biomaterial for Neural Regeneration3.7 Role of Schwann Cells in Spinal Cord Injury; References; Chapter 4: Stem Cell- and Biomaterial-Based Neural Repair for Enhancing Spinal Axonal Regeneration; 4.1 Stem Cell Therapy for Axonal Regeneration in Spinal Cord Repair; 4.1.1 Embryonic Stem Cells; 4.1.2 Neural Stem Cells; 4.1.3 Induced Pluripotent Stem Cells; 4.1.4 Mesenchymal Stem Cells; 4.2 Biomaterial and Stem Co-Transplantation in Neural Regeneration; References
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Chapter 5: Electric Field-Guided Cell Migration, Polarization, and Division: An Emerging Therapy in Neural Regeneration5.1 Electric Field Directing Axonal Growth; 5.2 Electric Fields Directing Neuron Migration; 5.3 EF-Guided Migration of Stem Cells and Stem Cell-Derived Neural Cells; 5.4 Oriented Cell Division in EFs; 5.5 Regulation of EF-directed Neuronal Migration; 5.5.1 Cell Polarization in EFs; 5.5.2 Calcium Signals Growth Cone Navigation and Neuron Migration in Applied EF; 5.5.3 Cell Membrane Receptors and Intracellular Signaling Pathways
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| Abstract
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This book focuses on current applications of glial cells in neural regeneration, especially in spinal cord repair. It introduces the application of a few types of glial cells including oligodendrocyte, astrocyte, Schwann cells, and stem cell derived glial cells in neural regeneration. The latest glial cell research with biomaterials, gene modification, and electrical signals is also summarized. This is an ideal book for undergraduate and research students in tissue engineering, neurobiology, and regenerative medicine as well as researchers in the field. This book also: Illustrates the application of glial cells including oligodendrocyte, astrocyte, Schwann cells, and stem cell derived glial cells in neural regeneration Broadens reader understanding of the current applications of glial cells in neural regeneration, especially in spinal cord repair Demonstrates the engineering of glial cells with biomaterials, gene modification, and electrical signals for neural regeneration.
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| Subject
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Bioengineering.
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Nerves-- Growth.
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Nervous system-- Regeneration.
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Neuroglia.
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Bioengineering.
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Biomedical engineering.
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Cellular biology (cytology)
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MEDICAL-- Physiology.
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Nerves-- Growth.
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Nervous system-- Regeneration.
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Neuroglia.
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Neurosciences.
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SCIENCE-- Life Sciences-- Human Anatomy Physiology.
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| Dewey Classification
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612.81046
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| LC Classification
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QP363.2
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