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" Targeted therapy of colorectal cancer subtypes / "
Peter Jordan, editor.
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BL
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| Record Number
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859876
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| Title & Author
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Targeted therapy of colorectal cancer subtypes /\ Peter Jordan, editor.
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| Publication Statement
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Cham, Switzerland :: Springer,, [2018]
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| Series Statement
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Advances in experimental medicine and biology,; volume 1110
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| Page. NO
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1 online resource (viii, 150 pages) :: color illustrations
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| ISBN
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3030027716
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: 3030027724
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: 9783030027711
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: 9783030027728
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3030027708
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9783030027704
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| Notes
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Includes index.
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| Contents
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Preface Chapter 1- Colorectal Cancer Subtypes- the current portrait. 1 Peter Jordan Chapter 2- Targeting colon cancers with mutated BRAF and microsatellite instability. 17 Paulo Matos and Peter Jordan Chapter 3 -- Targeting KRAS mutant CMS3 subtype by metabolic inhibitors. 50 Oscar Aguilera and Roberto Serna-Blasco Chapter 4- Targeting the PI3K Signalling as a Therapeutic Strategy in Colorectal Cancer. 77 Maria Sofia Fernandes, João Miguel Sanches and Raquel Seruca Chapter 5- Targeting PTEN in colorectal cancers. 117 Larissa Kotelevets, Mark G.H. Scott and Eric Chastre Chapter 6- Wnt signalling-targeted therapy in the CMS2 tumour subtype: a new paradigm in CRC treatment? 162 Cristina Albuquerque and Lucília Pebre Pereira Chapter 7- Impact of the microenvironment on tumour budding in colorectal cancer. 216 Laurent MC Georges, Laurine Verset, Inti Zlobec, Pieter Demetter, Olivier De Wever Chapter 8- Anti-EGFR Therapy to treat metastatic colorectal cancer: not for all 241 Marta Martins, André Mansinho, Raquel Duarte, Soraia Lobo Martins and Luís Costa Chapter 9- miRNAs as modulators of EGFR therapy in colorectal cancer. 282 Diane M. Pereira and Cecília M.P. Rodrigues Index.
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| Abstract
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In this book, a group of researchers shares their expertise on the identification and characterization of genetic colorectal cancer subtypes. They describe solid pathobiological knowledge on the distinct sporadic tumour subtypes, including the mutations found in oncogenes and tumour suppressor genes, the types of genomic instability encountered, and the cellular signalling pathways activated. The book content indicates opportunities for the development of further pathway-specific therapeutic drugs or drug combinations, allowing to cope with the appearance of resistant tumours. The nine chapters of this book cover the main aspects underlying colorectal cancer development but also of its therapeutic options, which have been undergoing substantial changes by moving from the use of general cytotoxic agents that affect rapidly growing cells to more tumour-specific drugs. In the first case, all dividing cells in the patient?s body are affected and this causes severe and debilitating side effects. In the second case, the increasing knowledge about the molecular genetics of tumours has led to a new generation of drugs, which specifically interfere with the cell survival pathways that are activated in a given tumour. This allowed to identify groups of patients for targeted therapy that is much better tolerated. The book is thus an interesting update for health professionals on the current knowledge on heterogeneity in colorectal cancer. In addition, it should inspire the drug-developing scientific community by highlighting potential therapeutic Achilles heels of distinct subtypes of colorectal cancer.
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Colon (Anatomy)-- Cancer-- Chemotherapy.
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Drug targeting.
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Rectum-- Cancer-- Chemotherapy.
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Colonic Neoplasms-- drug therapy.
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Drug Delivery Systems.
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Rectal Neoplasms-- drug therapy.
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Drug targeting.
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Rectum-- Cancer-- Chemotherapy.
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| Dewey Classification
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616.99/4347061
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| LC Classification
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RC280.C6T37 2018
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| NLM classification
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WI 529
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| Added Entry
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Jordan, Peter
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