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BL
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| Record Number
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859888
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| Title & Author
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HIV-1 latency /\ Guido Silvestri, Mathias Lichterfeld, editors.
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| Publication Statement
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Cham, Switzerland :: Springer,, [2018]
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| Series Statement
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Current topics in microbiology and immunology,; volume 417
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| Page. NO
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1 online resource
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| ISBN
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303002816X
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: 3030028178
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: 9783030028169
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: 9783030028176
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3030028151
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9783030028152
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| Contents
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Intro; Preface; Contents; 74 Molecular Control of HIV and SIV Latency; Abstract; 1 Introduction; 2 The HIV-1 and SIVmac Promoters; 3 Regulation of HIV-1/SIV Transcription; 3.1 Nuclear Topography; 3.2 Viral Integration Site; 3.3 Epigenetic Modifications of HIV-1/SIV Promoter; 3.4 Regulation of HIV-1 Transcription by Tat/P-TEFb; 3.5 The Role of Cellular Transcription Factors; 4 Post-transcriptional Regulation of HIV-1 Expression; 4.1 HIV-1 mRNA Processing and Latency; 4.2 Noncoding mRNAs and HIV-1 Latency; 5 Concluding Remarks; References
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5.1 Antiretroviral Drugs That Have Been Utilized in NHPs5.2 Future cART Regimen Development for NHPs; 6 Alternative Models; 6.1 Chinese-Origin Rhesus Macaques; 6.2 RT-SHIV Infections; 6.3 SIVagm.sab Infections; 6.4 CNS Infection Models; 6.5 Envelope SHIVs; 7 Virologic Assays; 7.1 PCR and RT-PCR-Based Assays; 7.2 In Situ Approaches; 7.3 Other Virologic Assessments; 8 Concluding Remarks; Financial Support; References; 89 SIV Latency in Macrophages in the CNS; Abstract; 1 Introduction; 2 HIV Infection and SIV Infection in the CNS; 3 New Insights on Macrophage Origin and Phenotypes
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73 Nonhuman Primate Models for Studies of AIDS Virus Persistence During Suppressive Combination Antiretroviral TherapyAbstract; 1 Introduction; 2 NHP/AIDS Models; 2.1 HIV-1 Infection of Nonhuman Primates; 2.2 Discovery of Simian Immunodeficiency Virus (SIV) and Simian AIDS; 2.3 SIV Infection in Different NHP Species; 3 Advantages of NHP Models for HIV/AIDS Cure Research; 4 Challenges for Using NHP/AIDS Models for HIV Cure Research; 4.1 Logistical Challenges; 4.2 Challenges in cART Administration to AIDS Virus Infected NHP; 5 Administration of Antiretroviral Drugs to NHPs
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75 Assays to Measure Latency, Reservoirs, and ReactivationAbstract; 1 Introduction; 2 Definitions; 3 The Viral Outgrowth Assay; 3.1 Assay Design and Rationale; 3.2 Recent Improvements and Potential Problems with the QVOA; 4 The Proviral Landscape: Defective and Non-induced Proviruses; 5 Other Reservoir Assays; 5.1 PCR and Hybridization-Based Assays; 5.2 Induction Assays; 6 Other Approaches to Reservoir Measurement; 6.1 Residual Viremia; 6.2 Biomarkers; 6.3 Time to Rebound; 7 Conclusions; Acknowledgements; References; 72 The Antiviral Immune Response and Its Impact on the HIV-1 Reservoir
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Abstract1 Introduction; 2 Innate Immune Response; 2.1 Type I Interferon and Restriction Factors; 2.2 Natural Killer Cells; 3 Adaptive Immune Response: Humoral Immunity; 3.1 HIV-1-Specific Antibodies; 3.2 The Development of Broadly Neutralizing Abs; 3.3 Abs as a Preventative or Therapeutic Treatment; 3.4 Bispecific Abs; 4 Adaptive Immune Response: Cellular Immunity; 4.1 HIV-1-Specific CD8+T Cells; 4.2 CD8+T Cell Responses in Patients with Natural Control of HIV-1 Infection; 4.3 CD8+T Cell Based Vaccines; 4.4 CD8+T Cell Based "Shock and Kill" Therapy; 5 Conclusions; References
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| Abstract
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This volume summarizes recent advances in understanding the mechanisms of HIV-1 latency, in characterizing residual viral reservoirs, and in developing targeted interventions to reduce HIV-1 persistence during antiretroviral therapy. Specific chapters address the molecular mechanisms that govern and regulate HIV-1 transcription and latency; assays and technical approaches to quantify viral reservoirs in humans and animal models; the complex interchange between viral reservoirs and the host immune system; computational strategies to model viral reservoir dynamics; and the development of therapeutic approaches that target viral reservoir cells. With contributions from an interdisciplinary group of investigators that cover a broad spectrum of subjects, from molecular virology to proof-of-principle clinical trials, this book is a valuable resource for basic scientists, translational investigators, infectious-disease physicians, individuals living with HIV/AIDS and the general public.
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| Subject
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HIV (Viruses)
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HIV infections.
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Epidemiology medical statistics.
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HEALTH FITNESS-- Diseases-- General.
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HIV (Viruses)
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HIV infections.
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Immunology.
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Medical microbiology virology.
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MEDICAL-- Clinical Medicine.
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MEDICAL-- Diseases.
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MEDICAL-- Evidence-Based Medicine.
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MEDICAL-- Internal Medicine.
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Pathology.
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| Dewey Classification
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616.97/92
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| LC Classification
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QR201.A37
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| Added Entry
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Lichterfeld, Mathias
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Silvestri, Guido, (Professor of pathology and laboratory medicine)
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