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BL
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| Record Number
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860398
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| Title & Author
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Pharmaceuticals from microbes : : impact on drug discovery /\ editors, Divya Arora, Chetan Sharma, Sundeep Jaglan and Eric Lichtfouse.
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| Publication Statement
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Cham, Switzerland :: Springer,, [2019]
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| Series Statement
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Environmental chemistry for a sustainable world,; volume 28
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| Page. NO
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1 online resource
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| ISBN
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3030046753
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: 3030046761
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: 9783030046750
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: 9783030046767
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3030046745
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9783030046743
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| Bibliographies/Indexes
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Includes bibliographical references and index.
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| Contents
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Intro; Preface; Contents; Contributors; Chapter 1: Pharmacological Potential of Marine Microbes; 1.1 Introduction; 1.2 Marine Microbes: The Latent Sources of Bioactive Compounds from Marine Macroorganisms; 1.3 Antibacterial Activity; 1.4 Antifungal and Antiviral Activity; 1.5 Anti-inflammatory Activity; 1.6 Anticancer Activity; 1.7 Antituberculosis and Anticholinesterase Activity; 1.8 Antimalarial Activity; 1.9 Antidiabetic Activity; 1.10 Novel Metabolites Produced by Marine Actinomycetes; 1.11 Miscellaneous Pharmacological Activities of Marine Microbes
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1.12 Supply Issue of Bioactive Compounds from Marine Resources1.13 Conclusion; References; Chapter 2: Antiparasitics from Microorganisms; 2.1 Introduction; 2.2 Global and National Status of Parasitic Infections; 2.3 Chemotherapeutics Against Parasitic Infections; 2.3.1 Antiparasitic Drugs Developed from Microbial Metabolites; 2.3.2 Discovery of New Drug Candidates from Microbial Resources; 2.3.3 New Drug Targets and Screening Assays/Technologies; 2.4 Conclusion; References; Chapter 3: Bioactive Compounds from Nocardia: Biosynthesis and Production; 3.1 Introduction
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3.2 Classification and Taxonomy3.3 Bioactive Compounds from Nocardia spp. and Their Biological Significance; 3.3.1 Nocardicins; 3.3.2 Nocobactin; 3.3.3 Nocardithiocin; 3.3.4 Nargenicin; 3.3.5 Biosynthesis of Other Metabolites from Nocardia spp.; 3.4 Metabolic Engineering for Production of Bioactive Compounds from Nocardia spp.; 3.5 Future Perspective; 3.6 Conclusion; References; Chapter 4: Bioactive Metabolites Isolated from Microorganisms for Healthcare: Types and Delivery Routes; 4.1 Introduction; 4.2 Bioactive Metabolites as Therapeutics
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4.2.1 Microbial Metabolites Having Antidiabetic Properties4.2.2 Microbial Metabolites Having Anticancerous Properties; 4.2.3 Microbial Metabolite Having Antibacterial Properties; 4.2.4 Microbial Metabolites Having Antifungal Properties; 4.3 Delivery of Bioactive Compounds; 4.3.1 Oral Delivery of Bioactive Compounds; 4.3.2 Intradermal Delivery of Bioactive Compounds; 4.3.3 Intravenous Delivery of Bioactive Compounds; 4.4 Conclusions; References; Chapter 5: Siderophores: A Novel Approach to Fight Antimicrobial Resistance; 5.1 Introduction; 5.2 Bacterial Resistance and Current Needs
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5.3 Siderophore Iron Uptake System5.3.1 Siderophore Biosynthesis; 5.3.2 Classification of Siderophores; 5.3.3 Siderophores in Gram-Positive Versus Gram-Negative Bacteria; 5.3.4 Siderophores as Virulence Determinants; 5.4 Antimicrobial Applications of Siderophores; 5.4.1 Siderophore-Mediated Drug Delivery; 5.4.1.1 Siderophore-Trojan Horse Systems for Medical Diagnostic Imaging; 5.4.2 Inhibition of Siderophore Biosynthesis; 5.4.3 Iron Starvation via Competitive Chelation; 5.5 Conclusion; References; Chapter 6: An Update on Bioactive Natural Products from Endophytic Fungi of Medicinal Plants
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| Abstract
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This book deals with the noteworthy advancement in the production of bioactive metabolites from microbes and their pharmacological significance. It highlights the pharmacological potential of marine microbes and endophytic fungi and their bioactive secondary metabolites. Emphasis is also given on the significance of probiotics and their specialized molecules in human health and disease as well as their role in dietary intervention for reducing the risk of non-alcoholic fatty liver disease. This work also serves as excellent reference material for researchers, students and academicians in the field of natural product chemistry, pharmacology and applied microbiology.
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| Subject
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Drug development.
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Pharmaceutical microbiology.
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Drug development.
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MEDICAL-- Pharmacology.
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Pharmaceutical microbiology.
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| Dewey Classification
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615.1/9
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| LC Classification
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QR46.5
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| Added Entry
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Arora, Divya
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Jaglan, Sundeep
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Lichtfouse, Eric
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Sharma, Chetan
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