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BL
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860581
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| Title & Author
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Roles of host gene and non-coding RNA expression in virus infection /\ Ralph A. Tripp, S. Mark Tompkins, editors.
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| Publication Statement
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Cham, Switzerland :: Springer,, [2018]
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| Series Statement
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Current topics in microbiology and immunology ;; volume 419
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| Page. NO
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1 online resource
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| ISBN
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3030053687
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: 3030053695
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: 9783030053680
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: 9783030053697
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9783030053680
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| Bibliographies/Indexes
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Includes bibliographical references.
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| Contents
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Intro; Preface; Contents; 25 Host Factors in Coronavirus Replication; Abstract; 1 Introduction; 2 Host Receptors Involved in Coronavirus Entry; 3 Translation and the Unfolded Protein Response in Coronavirus-Infected Cells; 4 Coronavirus-Induced Modification of Host Cell Membranes; 5 Host Proteins Interacting with the Coronavirus Genome and Its Replication or Expression; 6 Host Innate Immune Responses Against Coronaviruses, and Viral Countermeasures; 7 Coronavirus-Induced Deregulation of the Cell Cycle; 8 The Role of Cyclophilins in Coronavirus Replication
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2.4.3 Translation Elongation2.4.4 Translation Termination and Recycling; 2.4.5 Ribosomal Proteins; 2.4.6 Polyprotein Biogenesis and Processing; 2.5 Viral RNA Synthesis; 2.5.1 Replication Complex (RC) Formation and RNA Synthesis; 2.5.2 RNA-Binding Proteins; 2.6 Particle Assembly; 2.7 Particle Egress; 2.7.1 Glycosylation; 2.7.2 Furin-like Protease Cleavage; Acknowledgements; References; 29 Role of Innate Genes in HIV Replication; Abstract; 1 Introduction; 2 Sensors of the Innate Response; 2.1 TLR Sensors; 2.2 Cytosolic Sensors; 3 HIV-1 Utilizes or Avoids Cellular Factors to Escape Sensing
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27 Host Factors Involved in Ebola Virus ReplicationAbstract; 1 Introduction; 2 Host Factors Required for Cell Entry and Fusion; 2.1 Attachment Factors; 2.2 Endosomal Uptake; 2.3 Glycoprotein Processing and Fusion; 3 Host Factors Required for Viral Transcription and Translation; 3.1 Viral Gene Expression and Genome Replication; 3.2 Viral Protein Synthesis; 4 Host Factors Required for Assembly and Egress; 5 Antagonism of Antiviral Responses; 5.1 Innate Immune Antagonism; 5.2 Adaptive Immune Antagonism; 6 Cell and Tissue-Specific Host Factors Involved in Pathogenesis; 7 Conclusion; References
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3.1 Cloaking of HIV-1 Cargo3.2 Exploitation of a Cellular Nuclease; 3.3 Active Exploitation of NLRX1; 3.3.1 NLRX1-A Regulator of Innate Signaling; 3.3.2 NLRX1-A Negative Regulator of HIV-1 Sensing; 3.3.3 Localization of NLRX1 and Signal Components; 3.3.4 Possible Impact of NLRX1 on Latent Reservoirs; 4 Restriction Factors as Effectors of the Innate Response; 5 SAMHD1-HIV-1 is Passively Avoiding Restriction; 5.1 Discovery of SAMHD1; 5.2 SAMHD1 Enzymatic Functions; 5.3 SAMHD1 Involved in Innate Immunity; 6 Conclusion; Acknowledgements; References
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9 Systems Biology Approaches to Identifying Host Factors in Coronavirus Replication10 Concluding Remarks; References; 26 Roles of Pro-viral Host Factors in Mosquito-Borne Flavivirus Infections; Abstract; 1 Introduction; 2 Anti- and Pro-viral Host Factors; 2.1 Attachment; 2.1.1 Glycosaminoglycans; 2.1.2 C-Type Lectin Receptors; 2.1.3 Phosphatidylserine Receptors; 2.1.4 Fc Receptors and Antibody-Dependent Enhancement of Attachment and Entry; 2.1.5 Other Receptor Types; 2.2 Endocytosis; 2.3 Uncoating; 2.4 Viral Translation; 2.4.1 Translation Initiation; 2.4.2 RNA Recruitment to the ER
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| Abstract
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This volume discusses the interactions between viruses and their host cells, and explores the roles of host and viral genes and non-coding RNAs in the virus replication cycle. During infection, viruses express a variety of genes, encoding proteins and RNAs that serve to subjugate the cell - by redirecting cellular processes to support viral replication and, at the same time, by mitigating the cellular response to infection. In this book, experts discuss these interactions in depth, and elaborate on our current understanding of virus-cell interactions for a diverse range of viruses, including positive and negative sense RNA viruses, DNA viruses, and a vector-borne virus. The roles of non-coding RNAs are also discussed. While each class of viruses has distinct replication requirements, this volume reveals unique features and commonalities in viral replication cycles. Accordingly, it represents a valuable source of information for researchers and clinicians alike.
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| Subject
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Non-coding RNA.
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Viral genetics.
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Non-coding RNA.
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Viral genetics.
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RNA, Untranslated.
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Virus Replication-- genetics.
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Host Microbial Interactions.
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Virus Diseases-- genetics.
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| Dewey Classification
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572.8/8
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| LC Classification
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QR456.R65 2018
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| NLM classification
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QW 160
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W1CU82K v.419 2018
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| Added Entry
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Tompkins, S. Mark
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Tripp, Ralph A.
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