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BL
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| Record Number
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863818
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| Title & Author
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Epigenetic regulation of skin development and regeneration /\ Vladimir A. Botchkarev, Sarah E. Millar, editors.
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| Publication Statement
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Cham, Switzerland :: Humana Press,, [2018]
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| Series Statement
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Stem cell biology and regenerative medicine
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| Page. NO
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1 online resource :: illustrations (some color)
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| ISBN
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3319167693
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: 9783319167695
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3319167685
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9783319167688
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| Bibliographies/Indexes
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Includes bibliographical references and index.
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| Contents
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Intro; Preface; Contents; Contributors; Chapter 1: All Roads Go to the Nucleus: Integration of Signaling/Transcription Factor-Mediated and Epigenetic Regulatory Mechanisms in the Control of Skin Development and Regeneration; 1.1 Introduction; 1.2 Development of the Epidermis and Skin Appendages: Transition from Single-Layered Epithelium to Multicellular Mini-Organs; 1.3 Distinct Classes of Skin Stem Cells as Sources for Postnatal Skin Regeneration; 1.4 The Nucleus as a Hub Transforming Signaling Information into Lineage- and Differentiation Stage-Specific Transcriptional Outcomes.
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1.5 Integration of Signaling/Transcription Factor-Mediated and Epigenetic Regulatory Mechanisms in the Control of Keratinocyte Differentiation and Stem Cell Activity1.6 Conclusions; References; Chapter 2: DNA Methylation as an Epigenetic Memory Keeper during Skin Development and Regeneration; 2.1 Introduction; 2.1.1 Skin as a Model for Epigenetic Regulation of Organ Development and Regeneration; 2.1.2 Principles of DNA Methylation; 2.2 DNA Methylation in Skin Development; 2.2.1 Dynamic DNA Methylation in the Early Embryo.
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2.2.2 DNA Methylation Fixes Skin Lineage Commitments during Embryonic Development2.3 DNA Methylation in Epidermal Renewal and Hair Cycling; 2.3.1 Maintenance of DNA Methylation Keeps the Identity of Epidermal Progenitor Cells in the Interfollicular Epidermis; 2.3.2 Roles of de novo DNA Methyltransferases in Epidermal Homeostasis; 2.3.3 DNA Methylation Maintains Hair Follicle Homeostasis; 2.3.4 DNA Methylation Orchestrates Hierarchies of Skin Lineages; 2.4 DNA Methylation in Skin Wound Healing; 2.5 Crosstalk between DNA Methylation and Histone Modifications in Skin.
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2.6 Potential for Future Applications2.7 Concluding Remarks; References; Chapter 3: Polycomb Proteins and their Roles in Skin Development and Regeneration; 3.1 Introduction; 3.2 Polycomb Discovery and Mechanistic Overview; 3.2.1 Mammalian PRC1 Complexes; 3.2.2 PRC1 Recruitment and Function; 3.2.3 Mammalian PRC2 Complexes; 3.2.4 Mammalian PRC2 Recruitment and Function; 3.3 The Roles of Polycomb in Skin Epithelium Differentiation and Development; 3.3.1 Epidermis; 3.3.2 Hair Follicles; 3.3.3 Merkel Cells; 3.4 The Role of Polycomb in Skin Wound Healing and Regeneration.
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3.5 Polycomb Proteins in Cancer3.6 Polycomb Proteins in Skin Aging; 3.7 Polycomb Proteins in Psoriasis; 3.8 Concluding Remarks; References; Chapter 4: Trithorax Genes in the Control of Keratinocyte Differentiation; 4.1 The history of Trithorax: Developmental Regulation Requires a Balance Between Trithorax and Polycomb Group Regulation; 4.2 Trithorax Complex Members Regulate Methylation of Lysine 4 on Histone H3; 4.3 The Functions of Mammalian Trithorax Complexes; 4.4 The Epidermis as a Developmental Model System.
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| Abstract
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This indispensable volume highlights recent studies identifying epigenetic mechanisms as essential regulators of skin development, stem cell activity and regeneration. Chapters are contributed by leading experts and promote the skin as an accessible model system for studying mechanisms that control organ development and regeneration. The timely discussions contained throughout are of broad relevance to other areas of biology and medicine and can help inform the development of novel therapeutics for skin disorders as well as new approaches to skin regeneration that target the epigenome. Part of the highly successful Stem Cells and Regenerative Medicine series, Epigenetic Regulation of Skin Development and Regeneration uncovers the fundamental significance of epigenetic mechanisms in skin development and regeneration, and emphasizes the development of new therapies for a number of skin disorders, such as pathological conditions of epidermal differentiation, pigmentation and carcinogenesis. At least six categories of researchers will find this book essential, including stem cell, developmental, hair follicle or molecular biologists, and gerontologists or clinical dermatologists.
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| Subject
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Genetic regulation.
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Genetic translation.
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| Subject
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Skin-- Growth-- Regulation.
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Skin-- Growth.
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Gene Expression Regulation.
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Protein Biosynthesis.
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Skin-- growth development.
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Cellular biology (cytology)
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Dermatology.
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Genetic regulation.
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Genetic translation.
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Genetics (non-medical)
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MEDICAL-- Physiology.
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SCIENCE-- Life Sciences-- Human Anatomy Physiology.
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Skin-- Growth.
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| Dewey Classification
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612.79
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| LC Classification
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QM484.E65 2018
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| Added Entry
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Botchkarev, Vladimir
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Millar, Sarah
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