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BL
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| Record Number
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863913
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| Title & Author
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Membrane dynamics and calcium signaling /\ Joachim Krebs, editor.
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| Publication Statement
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Cham, Switzerland :: Springer,, [2017]
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, ©2017
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| Series Statement
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Advances in experimental medicine and biology ;; 981
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| Page. NO
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1 online resource
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| ISBN
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3319558587
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: 9783319558585
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3319558579
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9783319558578
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| Bibliographies/Indexes
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Includes bibliographical references.
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| Contents
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Intro; Preface; Contents; Part I: Plasma Membrane; Chapter 1: The Plasma Membrane Calcium Pump (PMCA): Regulation of Cytosolic Ca2+, Genetic Diversities and Its Role in Sub-plas ... ; 1.1 Introduction; 1.2 General Properties of PMCA; 1.3 Structural Details of PMCA; 1.4 Genetic Diversity of PMCA in Health and Disease; 1.4.1 PMCA1; 1.4.2 PMCA2; 1.4.3 PMCA3; 1.4.4 PMCA4; 1.5 PMCA and Microdomains of Ca2+ Signaling; 1.6 Conclusions; References; Chapter 2: Structure-Function Relationship of the Voltage-Gated Calcium Channel Cav1.1 Complex; 2.1 Introduction
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3.3.1 CBD12 Crystal Structures Highlight the Functional Significance of the Two-Domain Interface3.3.2 Ca2+ Dependent Rigidification Underlies Dynamic Coupling of CBDs; 3.4 Structure-Dynamic Basis for Ca2+ Evoked Decoding of Regulatory Massage; 3.5 Exon-Specific Roles in Editing the Regulatory Massage; 3.6 Conclusions; References; Part II: Endoplasmic/Sarcoplasmic Reticulum; Chapter 4: The Endoplasmic Reticulum and the Cellular Reticular Network; 4.1 Introduction; 4.2 The ER; 4.3 ER and Ca2+ Homeostasis; 4.4 ER-Plasma Membrane Connection: Store-Operated Calcium Entry
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4.5 ER and Protein Quality Control4.6 ER and Cellular Stress Coping Response Strategies; 4.7 ER and Lipid Metabolism; 4.8 ER and Membrane Contact Sites; 4.9 Conclusions; References; Chapter 5: Structure-Function Relationship of the SERCA Pump and Its Regulation by Phospholamban and Sarcolipin; 5.1 Calcium Homeostasis; 5.2 SERCA Isoforms and Human Disease (P-Type ATPases); 5.2.1 SERCA1; 5.2.2 SERCA2; 5.2.3 SERCA3; 5.3 Catalytic Cycle of Calcium Transport by SERCA; 5.4 Structural Studies of SERCA; 5.4.1 Structural Insights into the SERCA Calcium Transport Cycle
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Chapter 3: Structure-Dynamic Coupling Through Ca2+-Binding Regulatory Domains of Mammalian NCX Isoform/Splice Variants3.1 Ca2+ Sensing by Isoform/Splice Variants and Multitask Ca2+ Signaling; 3.2 Structural and Regulatory Specificities of NCX Isoform/Splice Variants; 3.2.1 Coordination Chemistry Controls the Number and Affinity of Ca2+ Sites in Uniformly Folded CBDs; 3.2.2 Each CBD Domain Plays a Distinct Regulatory Role; 3.2.3 Exon Arrays Differentially Control the Tissue-Specific Regulatory Modes of NCX Variants; 3.3 Synergistic Interactions Between CBDs Control the Ca2+ Sensing Features
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| Abstract
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"This book describes the newest discoveries on calcium signaling happening at the cellular and intracellular membranes, often exerted in so called microdomains. Calcium entry and release, its interaction with proteins and resulting events on proteins and organelles are comprehensively depicted by leading experts in the field. Knowledge about details of these highly dynamic processes rapidly increased in recent years, the book therefore provides a timely summary on the processes of calcium signaling and related membrane dynamics; it is aimed at students and researchers in biochemistry and cell biology."--
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| Subject
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Calcium channels.
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Calcium-- Physiological effect.
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Cell membranes.
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Cell receptors.
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Cellular signal transduction.
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Biophysics.
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Calcium channels.
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Calcium-- Physiological effect.
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Cell membranes.
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Cell receptors.
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Cellular biology (cytology)
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Cellular signal transduction.
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Proteins.
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SCIENCE-- Life Sciences-- Biochemistry.
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Calcium Signaling.
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Cell Membrane-- physiology.
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Calcium Channels.
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Cell Physiological Phenomena.
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Membrane Microdomains-- physiology.
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Signal Transduction.
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| Dewey Classification
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572/.516
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| LC Classification
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QP535.C2
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| NLM classification
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QU 55.2
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| Added Entry
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Krebs, J., (Joachim),1940-
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